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Yu-Shiba-Rusinov (YSR) states result from the exchange coupling between a localized magnetic moment and a superconductor. Traditionally, the YSR states have been studied for magnetic atoms. For molecular magnets with extended ligand spin, the entanglement of spin and ligand orbital gives rise to new forms of YSR excitations. Here, Xia et al uncovered spin-orbital YSR states in an unpaired ligand spin in the molecular magnet Tb2Pc3 on Pb.

Slow electrolyte desolvation can impact kinetics in hard carbon-based electrodes, limiting low-temperature cyclability. Here, authors design a co-intercalation electrolyte which bypasses slow desolvation, enabling an Ah-level pouch cell with a specific energy density of 107 Wh kg⁻¹ at −50 °C.

Protein C-terminal diversity is widespread, yet its proteome-wide impact remains unclear. Here, the authors show that C-terminal variations influence the stability of canonical and disease associated mutant proteins and define the sequence features and degradative mechanisms underlying this regulation.

Here the authors engineer dual spillover of H* and CO* on PdHx/Cu to enhance urea electrosynthesis, where CO* spillover from PdHx surface to Cu facilitates initial C–N coupling while H* spillover from PdHx lattice to Cu promotes C–N intermediate protonation.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

GLT25D1 galactosylates collagen hydroxylysines and is essential for collagen maturation. Here, authors trap multiple functional states of GLT25D1 to elucidate its molecular mechanism, providing mechanistic insights into GLT25D1-related diseases.

The mechanical microenvironment for MSCs is crucial for osteogenesis. Here, the authors developed a hydrogel in which MSC-secreted ALP actively remodels the surrounding heterogeneous mechanical microenvironment to promote osteogenesis for bone regeneration.

Lithium metal offers high specific capacity but suffers from dendrite growth and poor cycling stability. Here, authors develop a 3D Li-Zn-Li3N/CNT composite combining ductile Li-Zn alloy and a mechanically robust Li3N-CNTs network, enabling thin, durable electrodes with uniform lithium deposition, demonstrating a pouch-cell with a specific energy of 553 Wh kg-1.

This study presents the inhibitory primary auditory cortex – anterior cingulate cortex pathway underlying the auditory-pain crosstalk in mice, thus serving as a neural substrate for music therapy in visceral pain management.

Osteoarthritis encompasses multiple pathological processes making it difficult to treat. Here, the authors develop ROS/MMP13 dual-responsive organic selenium hydrogel microspheres (HSPHR) to modulate intra-articular multi-tissue selenoprotein levels, achieving multimodal treatment.

This study shows that promoter and enhancer functions are often linked within the same DNA sequences. Using a dual-reporter assay, the authors reveal shared sequence features and co-dependent activities supporting a unified model of gene regulation.

BUC-95’s unique stretchable structure overcomes the inherent electron transfer limitations from Fe sites to peroxydisulfate and achieves the formation of Fe(IV) = O species, enhancing the ofloxacin degradation performance.

This study demonstrates that the reduced serum serine in patients with chemotherapy or women with poor sleep, is linked to the decline of ovarian function. Serine supplementation prevented ovarian damage in mice by inhibiting ferroptosis in ovarian granulosa cells, without affecting chemotherapy efficacy.

A low thermal expansion chromium alloy overcomes inherent brittleness via atomic faulting in layered precipitates. This tough, corrosion-resistant material enables stable components for extreme environments.

Intestinal glucose excretion is a gut-based mechanism contributing to improved glycemic control after weight-loss surgery. Here, the authors describe a signaling pathway that drives intestinal glucose uptake and luminal excretion, identifying a potential therapeutic target for diabetes and weight loss.

Phage therapy is emerging as a promising alternative to antibiotics for treating various infections. However, there have been no prior studies on the use of bacteriophages for peritonitis in patients undergoing peritoneal dialysis. Authors present a successful case of treating refractory peritonitis in a 71- year-old male patient on peritoneal dialysis using bacteriophages combined with antibiotics.

Heart failure affects millions worldwide with limited treatment options. Here, the authors develop a biodegradable, self-powered vagus nerve stimulator that attenuates cardiac damage at different disease stages without requiring battery replacement or surgical removal.

This study reveals that during a series of learning tasks, the macaque brain represents the shared (e.g. the decision strategy) and task-unique information (e.g., sensory inputs) in a near-orthogonal manner, thereby supporting reuse of the shared component to facilitate learning, while remain flexible to changes in specifics.

Modifying the light-absorbing or catalytic properties of a photocatalyst typically requires tedious preparation, resulting in a lengthy development process. Here, the authors address this limitation by achieving manganese-based low-energy photoredox catalysis through the in-situ assembly of simple Mn salts with inexpensive coordinating chemicals.

Authors uncover the tunable band structure in ferroelectric rhombohedral-stacked bilayer WSe₂ by optical spectroscopy, quantifying spontaneous polarization and demonstrating electric-field-driven domain switching for quantum device applications.

Spectroscopy often relies on bulky instrumentations implementing a single technique. Here, authors propose an on-chip, lithium niobate, multi-functional platform demonstrating photodetection and gas sensing. The latter is realised through photoacoustic or thermoelastic sensing, achieving parts-per-billion detection limits.

Authors in this study report cryo-EM structures of human V1aR in its apo state and in complexes with antagonists. Structural analyses reveal a dimeric assembly, flat ECL2 with unpaired cysteines in apo state, and uncover distinct binding modes and key determinants for antagonism and selectivity.

The role of the innate immune system in pancreatic cancer is largely unexplored. Here, the authors reveal a targetable cancer cell-intrinsic axis in pancreatic cancer comprising ASC inflammasome complexes that link innate immunity with mitochondrial function and metabolism.

Authors develop a superelastic, tellurium-based visual-tactile sensor for endoscopes. It enables simultaneous visual, thermal, and force sensing, successfully identifying inflamed tissues in live trials where visual data alone failed.

Pluripotent stem cells are found throughout the planarian body but regenerate organs in distinct regions. This study shows that the receptor RoboA and the secreted protein Anosmin1a act as signals that restrict stem cell plasticity and differentiation.

GDF15 has been associated with cancer-associated cachexia. Here, the authors show that STK11/LKB1 loss-of-function mutations in non-small cell lung cancer result in an exaggerated integrated stress response culminating in the tumor cell secretion of the cytokine GDF15 promoting cachexia.

Plastic foams are widely used across industry, but petroleum-based materials are unfavorable. Here the authors report a cellulose-based molecular foam for thermal management as an environmentally friendly alternative.

In this work, authors present a modular design for solid oxide fuel cell systems, aiming to enhance scalability and efficiency. It achieves 66.3% electrical efficiency, reduces water use by 60%, and fresh air demand by 22%, offering a cost-effective solution for large-scale power generation.

In this study, authors reveal an evolutionary strategy in bacteria, where multidrug resistance are stably maintained through multicopy heterogeneous genes on a single plasmid, conferring an adaptive advantage under fluctuating clinical drug pressures.

KIAA1199 is upregulated in colorectal cancer (CRC), associated with metastasis and poor clinical outcomes. Here the authors report that extracellular vesicles secreted by KIAA1199-high CRC cells functionally reprogram hepatocytes to support the infiltration of Egr1⁺ neutrophils, resulting in accelerated liver metastatic colonization.

Here they identify a functional Thyroid Hormone protein precursor in ascidian, named ScTG-like, and detected the follicle-like structure for TH synthesis. These findings suggest TG-like proteins are conserved in bilaterians, providing insight into the evolution of TH synthesis.

This study reports the design of a MOF-on-MOF heterojunction catalyst with interfacial dual active sites for efficient urea production via photocatalytic co-reduction of nitrate and carbon dioxide.

In multi-path interference experiments, the different possibilities of partitioning reality into alternatives represented by probability amplitudes can lead to unexpected consequences. Here, the authors study the interplay between interference and which-source information in a frustrated SPDC system with three nonlinear crystals, showing that even in the case of full which-source information, it is impossible to ascribe a definite origin to photon pairs.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Staphylococcus aureus can aggregate within human synovial fluid and lead to joint infections. Here, the authors reveal that the fatty acid kinase system and its downstream saeRS regulator control S. aureus aggregation within synovial fluid.

Cervical spondylosis is a highly prevalent degenerative disease that lacks visible lesions on medical images, making its diagnosis heavily reliant on scarce expert experience. Here the authors show a cascade-ensemble deep learning framework that achieves expert-level accuracy in diagnosing cervical degeneration by integrating multi-modal imaging data and analyzing key clinical indicators

Recovering nitrate from surface water can help address interconnected environmental, resource, and energy challenges. A bioinspired photothermal evaporation platform enabling the co-recovery of low-concentration nitrate and freshwater is proposed.

Type 1 Innate Lymphoid cells (ILC1s) regulate the disease progression in murine models of acute myeloid leukaemia (AML). Here, the authors show that human ILC1s are impaired in patients with AML, and human umbilical cord blood-generated ILC1s can inhibit leukemia stem cell differentiation and limit AML development, suggesting a potential therapeutic approach.

Lithium metal batteries face challenges of unstable interfaces and slow ion transport. Here, authors report a hydrogen-bonded domain electrolyte based on addition of 2-cyano-N-methylacetamidethat as cosolvent which enhances ion transport and interface stability, enabling long cycling high voltage (up to 4.7 V) Li | |LiNi0.8Co0.1Mn0.1O2 batteries with high specific energy of 418.2 Wh kg⁻¹.

Many vascular‑disease risk loci lack defined causal genes. Here, the authors integrate functional genomics and CRISPR screens to identify genes influencing smooth muscle cell behaviour, validating roles for FES, BCAR1, CARF and SMARCA4, with Fes loss promoting atherosclerosis and hypertension.

Authors show that Ag₂Te achieves room-temperature plasticity via stress-driven silver ion hopping, which enables crystal rotation, combining high flexibility with efficient thermoelectric performance for wearable electronics.

Migrasomes mediate the release of cytoplasmic contents, thereby facilitating intercellular communication. Here, the authors propose a regulatory mechanism underlying migrasome biogenesis and elucidate how viruses exploit this pathway to promote cell-to-cell transmission.

Enhancing the carrier mobility of graphene can enable the investigation of its fundamental properties and promote device applications. Here, the authors report the fabrication of double-layer graphene devices with a quantum mobility up to 10⁷ cm²V⁻¹s⁻¹ and integer quantum Hall features at magnetic fields as low as 0.002 T.

Deep brain stimulation is effective but invasive. Here, the authors develop an injectable conductive hydrogel that forms in situ and enables wireless neuromodulation under volume conduction via capacitive coupling, showing therapeutic potential in a Parkinson’s disease rat model

Sulfur electrodes are typically fabricated by solvent slurry casting with polymer binders, adding complexity. Here, authors show that the intrinsic binding properties of sulfur enable polymer- and solvent-free electrode fabrication, delivering durable cycling while potentially reducing manufacturing cost.

Low outcrossing rate of sterile lines limits hybrid rice seed production. Here, the authors report that mutation of a SET domain-containing protein HER1 leads to enlarged stigma, enhanced stigma exsertion, and hybrid seed production in rice.