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The authors identify Npr1 as a nucleophagy receptor in fission yeast that acts redundantly with Epr1 to degrade nuclear components. Tethering chromatin to the inner nuclear membrane blocks nucleophagy, suggesting a genome protection mechanism.

Removing trace acetylene from ethylene is vital for plastic production, yet catalysts often overreact and waste the product. This work reveals that palladium dual-atom catalyst on carbon greatly speeds the reaction while keeping ethylene intact.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Biological nitrogen fixation is crucial for soil fertility and is often attributed to bacteria. This study reveals that viruses can facilitate bacterial nitrogen fixation by encoding the auxiliary metabolic gene nifU.

Single-cell DNA methylation tracks developmental cell-state transitions, but existing methods struggle to model gradual changes over pseudotime. Here, authors introduce a Bayesian approach that estimates stage-specific variability and finds dynamic methylation.

Alternative splicing may help explain genetic risk for joint diseases. Here, the authors generate cartilage and synovium sQTL maps, revealing tissue‑specific splicing variants and pinpointing effector genes for osteoarthritis, rheumatoid arthritis, and height

Both endogenous and exogenous signaling pathways are involved in the maintenance of self-renewal and pluripotency of human embryonic stem cells (hESCs). Here, the authors uncover that endogenous VEGF signaling safeguards pluripotency and prevents extra-embryonic differentiation in primed hESCs via activation of transcription factor NANOG and suppression of BMP signaling activity.

Periodic strain in perovskite limits the stability of perovskite solar cells. Li et al. report a dynamic cross-linking strategy to regulate perovskite strain via reversible disulfide bond ring opening/closing reaction, enabling a 26.5% efficiency in solar cells with 95.7% retained after 1,800 h day-night cycling conditions.

Halide solid electrolytes typically require high lithium content, raising costs and exacerbating air sensitivity. Here, authors leverage anion clusters to synthesize an amorphous electrolyte with low lithium content of 2.4 wt%, high ionic conductivity of 1.5 mS cm^-1, and good air-stability.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Drug discovery often lacks complete multimodal molecular data. Here, the authors introduce M2UMol, a framework that transfers multimodal knowledge into 2D structures, enabling accurate predictions with missing modalities across diverse tasks.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Long-lived trapped-ion entanglement over 10 km of spooled fibre reaches the threshold where establishment exceeds loss, providing a critical building block for scalable quantum repeaters.

Achieving photo-thermal stability and device operational stability of tin-lead perovskite solar cells remains a major challenge. Here, authors replace tin fluoride additive by lead powders followed by lead fluoride post-treatment, achieving efficiency of 24.07% in stable tin fluoride-free devices.

Slow sulfur redox limits the development of wide-temperature-range Na-S batteries. Here, authors prepare Sn-doped CoNiS multipods catalyst with amorphous–crystalline interfaces that accelerate polysulfides conversion, enabling high-capacity and long-life batteries operated from −20 to 50 °C.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

The efficiency of selenium photovoltaics is hindered by the poor crystallization of the Se film. Wen, Li, Lu and colleagues use light to initiate Se crystallization, suppressing dewetting and enabling the formation of a continuous film, which achieves a certified efficiency of 10.3%.

An enzyme that specifically recognizes dephospho-CoA (dpCoA)-capped RNAs is used to quantify dpCoA-RNAs in cells.

Aqueous Zn | |I2 batteries, involving I-/I0/I+ redox, are promising yet usually facing low I2 utilization dominated by I0/I+ redox, especially under high loadings. Here, authors report a carbon-halogen bond substitution with a noncorrosive organohalide additive (2-bromoacetamide, BrAce) for a more thermodynamically favourable I0/I + , improving battery cycling under high loading and current conditions.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Rare earth-doped luminescent materials typically emit characteristic fluorescence, but achieving non-characteristic emissions remains challenging. Here, the authors report unique blue emissions from ytterbium- and erbium-doped organic-inorganic metal halides, demonstrating high water resistance and a ~ 90% quantum yield in solution, highlighting their potential as liquid-phase X-ray scintillators

Noise-induced hearing loss is commonly attributed to direct damage to sensory hair cells. Here, the authors reveal that non-sensory supporting cells play a critical role in the damage through Gasdermin D-mediated exacerbation of hair cell oxidative stress.

Hepatokine FGL1 mediates liver-kidney crosstalk in renal fibrosis. Upregulated by circulating inflammatory cytokines post-injury, it binds ALK5 to potentiate TGF-β signaling and promotes fibrotic progression, presenting a promising target for CKD.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

The E3 ubiquitin ligase NLA postively regulates cold tolerance and negatively regulates phosphate uptake in maize, and a genetically engineered variant of this enzyme leads to improved cold tolerance and enhanced phosphate uptake, improving yield in field trials.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

A general protocol for high-dimensional entangling gates is developed and applied for two four-dimensional qudits encoded in orbital angular momentum (OAM). The phase-locking technique stabilizes OAM sorters, leading to a process fidelity within a range from 0.71 to 0.85.

Multi-omics profiling of the mucosal mycobiome in individuals with Crohn’s disease identifies C. sphaerospermum as a protective fungal species that counteracts intestinal inflammation and reinforces the intestinal barrier.

Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer metastasis. Here, the authors reported a single-cell mechanophenotyping chip that screens deformable CTCs to reveal the hematogenous metastatic potential of bacteria-infected breast cancer.

This study identifies GCN5, a histone acetyltransferase, as a driver of metabolic dysfunction-associated steatotic liver disease progression via LXRα/SREBP1c-mediated lipogenesis, and demonstrates that pharmacological inhibition of GCN5 alleviates disease in a study with male mice.

Though wearable gloves are widely used for gesture associated applications (e.g. sign language recognition), sentence identification of sign language remains a challenge. Here, the authors report AI-enabled recognition system helps barrier-free communication between signers and non-signers.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

A sustainable approach to wastewater treatment is achieved through pollutant polymerization, polymer recovery and catalyst reuse, enabled by the design of a Ni–Zn layered double hydroxide catalyst.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A composite sorbent combining LiCl with MOF material Ni₂Cl₂(BTDD) enables high water uptakes while low desorption temperature, achieving solar-driven water yield over 1 L m^‒2 day^‒1, which has been confirmed in field tests even across diverse regions.

In this study, the authors conduct experiments involving 276 soil-derived microcosms to reveal that the ecological process of necromass recycling promotes diversity maintenance in bacterial communities. This mechanism could help explain how high microbial species diversity is maintained in natural soil communities.