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Spin transport properties of magnetically ordered materials have been well studied. Here, the authors report an anomalous spin signal exhibiting spin transport over 480 microns in the frustrated hyperkagome magnetic insulator Gd₃Ga₅O₁₂.

Mechanisms of siphophage infection in Gram-positive bacteria remain poorly understood. Here, the authors report the high-resolution structure of phage NF5 and visualize its cell wall adsorption and genome delivery process.

On-chip circularly polarized light (CPL) detectors are relevant for various applications, but current approaches have shown a trade-off between wide spectral detection range, high discrimination ratio and high polarization sensitivity. Here, the authors report broadband high-performance CPL detectors based on twisted black phosphorus structures.

A recent randomised controlled trial demonstrated effectiveness of a smart pillbox for oral HIV pre-exposure prophylaxis adherence in men who have sex with men in China. Here, the authors show that the intervention is cost effective, with greater benefits for more socially vulnerable groups.

The molecular heterogeneity of brain metastases (BrMs) poses challenges for their treatment. Here, the authors generate a multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer BrMs and identify four molecular subtypes with distinct biological and clinical features.

The advancement of bioorthogonal bond-breaking chemistry requires precise spatiotemporal control over chemical reactions. Here, the authors introduce a stimuli-responsive click–release platform based on the reaction between mono-alkylhydroxylamine and cyclooctyne, enabling rapid and nearly complete payload release, and apply it to release of anticancer drugs and anaesthetics.

For proper mitochondrial inheritance, paternal sperm mitochondria must be eliminated. Here, authors identify ALKB-1 mediated tRNA demethylation as essential for this clearance in Caenorhabditis elegans, revealing an epitranscriptomic quality checkpoint tied to male fertility.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

In patients with immunotherapy-resistant, HPV-negative head and neck squamous cell carcinoma (HPV- HNSCC), cetuximab (EGFR inhibitor) is the standard of care but success is limited. Here, the authors report the results of their phase II trial investigating dalpicilib (CDK4/6 inhibitor) and cetuximab in patients with immunotherapy resistant HPV- HNSCC.

This study demonstrates that the reduced serum serine in patients with chemotherapy or women with poor sleep, is linked to the decline of ovarian function. Serine supplementation prevented ovarian damage in mice by inhibiting ferroptosis in ovarian granulosa cells, without affecting chemotherapy efficacy.

Purinergic signalling dysregulation can drive inflammatory disorders, but effective targeted therapy is still lacking. Here, authors develop a smart DNA origami nanodevice that can precisely sense and metabolize high levels of extracellular ATP, thereby fine-tuning purinergic signalling and immune homeostasis.

The study demonstrated that some exogenous natural polysaccharides could be absorbed in plasma with little degradation after orally administration. Polysaccharide uptake in the intestinal cells relied on clathrin/dynamin 1/Rab5-dependent endocytosis.

Transition-metal-catalyzed nitrene strategies exhibit high efficacy for intermolecular N–H insertion, but nitrene-mediated N–N coupling under metal-free conditions has rarely been explored. Herein, the authors report the selective N–N coupling using sulfilimines as nitrene precursors.

Here the authors systematically benchmark 13 polygenic score (PGS) methods in UK Biobank European and African populations, revealing factors that affect prediction accuracy. They also introduce an automated platform for standardized and reproducible PGS computation.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

China’s carbon neutrality and clean-air policies cause global warming from reduced aerosols that nearly offsets cooling from reduced CO2 before 2060, with warming emerging afterwards, calling for early carbon neutrality and more mitigation strategies.

Recent studies have shown the potential of higher-order exceptional points originating from the Liouvillian dynamics as opposed to their Hamiltonian counterparts. Here, the authors explore different classes of third-order Liouvillian exceptional points in a two-level system realised in a single trapped ion.

Polygenic scores often underperform in non‑European ancestries. Here, the authors present GPTL, an R package with three transfer‑learning methods that improve cross‑ancestry PGS using either individual‑level data or GWAS summary statistics.

Metal–ligand synergistic catalysis remains underexplored in single-atom systems. Here, inspired by homogeneous pincer complexes, the authors construct Pd(II)–N₄ sites on carbon nitride, enabling highly selective photocatalytic semi-hydrogenation of alkynes.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

This study reveals a hierarchical development of the brain’s structural connectome from infancy to childhood, characterized by distinct sensorimotor-association trajectories and alignment with multiple neurobiological hierarchies.

Doxycycline has been recommended as post-exposure prophylaxis for prevention of bacterial sexually-transmitted diseases. Here, the authors use mathematical modelling to investigate the potential disease, antimicrobial resistance, and economic implications of this intervention in gay, bisexual, and other men who have sex with men in Australia.

Metal-cation-free CO₂ electroreduction in strong acid minimizes reactant loss and salt precipitation yet struggles with CO₂ activation and hydrogen evolution competition. Here, the authors report bioinspired sharp gold triangles with a proton-blocking layer that polarize CO₂ and suppress hydrogen evolution.

This work describes a Pd−B diatomic catalyst that can selectively catalyze the photosynthesis of glycine via C−N coupling reaction between PET-derived ethylene glycol and nitrate, achieving a yield of 2.9 mmol g_cat⁻¹ h⁻¹ and selectivity of 92%.

Cystine levels in pancreatic ductal adenocarcinoma (PDAC) tumour microenvironment are deficient, despite its crucial role for cancer cell maintenance. Here, the authors show that adaptation to cystine limitation stress promotes PDAC growth through induces metabolic reprogramming to promote PDAC tumor growth, while conferring a vulnerability in lipid metabolism targetable by lomitapide.

CRISPR-Cas12a diagnostics are limited by strict PAM requirements. Here, authors show that higher temperatures activate numerous noncanonical PAMs, enabling a versatile one-pot platform that improves sensitivity, specificity, and rapid on-site pathogen detection.

Hepatectomy is an important part of hepatocellular carcinoma (HCC) treatment but postoperative recurrence limits long-term survival. Here, the authors report a phase II clinical trial investigating perioperative tislelizumab (anti-PD-1) and lenvatinib (multi tyrosine kinase inhibitor) in patients with resectable HCC with a high-risk of recurrence.

In the phase III NAPOLI-3 trial, first-line treatment with NALIRIFOX was associated with improved overall survival compared to gemcitabine plus nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma. Here the authors report the results of a randomized phase II trial comparing the two regimens, NALIRIFOX versus Gemcitabine plus Nab-Paclitaxel, in Chinese patients.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Traditional urea production is energy-intensive and emits large amounts of CO₂. Here, the authors report an Ag/CdO catalyst with tandem dual sites that electrosynthesizes urea efficiently from nitrate and CO₂ by steering reaction pathways and suppressing by-products.

Spatial omics maps molecular features to tissue architecture, but it often misses rare cell populations. Here, the authors present GARDEN, a graph-based framework that detects pathogenic cells and regions across spatial omics, enables 3D tissue reconstruction, and reveals immune and regulatory mechanisms in several diseases.

Barcoding aids in the optimization of lipid nanoparticles. Here, the authors report on multiplexed mRNA barcoding that enables high-resolution spatiotemporal profiling of lipid nanoparticles, linking accumulation kinetics to functional delivery and revealing zonal liver targeting.

The oxyhalogenation of methane to mono-halogenated products CH₃X (X = Cl, Br, or I) is among the most promising routes for methane utilization, yet current catalysts still suffer from limited product yields. Here, the authors report a CeO₂ nanorod catalyst with atomically dispersed Pd and Mn surface sites, which achieves highly efficient and selective methane oxychlorination.

Phage therapy is an alternative treatment against biofilm-associated infections. In this case report, phage-antibiotic therapy was used to treat a vascular graft infection caused by a refractory fluoroquinolone non-susceptible Pseudomonas aeruginosa.

Achieving directional ion transport in thin membranes is desirable yet challenging. Here, authors demonstrate an ultrathin ferroelectric single-pore membrane that enables polarization-driven ion rectification and hysteretic responses under pH stimuli.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Transferring genetic materials between distantly related yeasts, presents technical challenges but can yield industrially interesting phenotypes. Here the authors establish a method to transfer individual chromosomes from Saccharomyces cerevisiae into Kluyveromyces marxianus.

The current unbalance between the performance of n-type and p-type 2D transistors limits their applications for next-generation electronics. Here, the authors report the realization of high-performance 2D MoTe₂ p-type transistors by depositing metallic tellurium contacts via thermal evaporation.

This study shows that the mechanical weakness of the mantle in the Tyrrhenian Basin leads to its exhumation at the continent-ocean transition, which is simultaneously punctuated with discrete oceanic crust.

Single-crystal alloy thin films (SATFs) are appealing for applications in crystal epitaxy, surface catalysis, and energy conversion. Here, the authors report a method to synthesize wafer-scale binary and ternary SATFs with sub-nanometer roughness, which can be used as substrates for the growth of high-quality graphene single crystals.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

Rancid odors trigger retching and aversion. Here, authors show a nose-to-brain axis whereby such odors activate olfactory-piriform circuits that diverge to mediodorsal thalamic nucleus and nucleus accumbens to mediate retching-like behavior and aversion.

AI models consume growing amounts of energy. Here, the authors introduce a brain-inspired way to prune connections in randomly weighted resistive-memory chips, boosting accuracy while avoiding costly analog tuning to improve general efficiency and reduce power use.

Fracto-mechanoluminescence is the emission of light from fracturing solids. Here, the authors show that this emission in Mn halides arises from elastic stiffness, electromechanical coupling, and trap states that activate Mn²⁺ d−d transitions.

The role of RNA-binding protein (RBP) phase separation in transcriptional regulation and its contribution to tumorigenesis remains to be characterised. Here, the authors show that RBP AKAP95 physically co-condenses with the mixed lineage leukemia 1 (MLL1) translocated fragment commonly found in MLL rearranged (MLLr) leukemia to promote leukemogenesis.

Stone tools illustrate behavioural complexities in Middle Pleistocene hominin populations. Here, the authors present small dimensional flakes and hafted tools from Xigou, central China, dated to ~160–72 thousand years ago that demonstrate early, complex technological advancements.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

The development of sustainable water oxidation catalysts is crucial for hydrogen production, yet cobalt-based materials often suffer from instability. Here, the authors report that co-doping LiCoO₂ with nickel, iron, and palladium yields a durable electrode with stability of over 2,000 hours.