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Acute-on-chronic liver failure is a complex condition with varied definitions. Using unbiased clustering, the study identifies two distinct subtypes with markedly different 30-day mortality risks and highlights key determinants.

The catalytic enantioconvergent N-alkylation of hydrazine derivatives with alkyl halides offers an attractive route to chiral hydrazines, but remains challenging due to the lack of efficient asymmetric catalytic systems and the difficulty in achieving regioselectivity. Herein, the authors report the copper-catalyzed enantioconvergent N-alkylation of hydrazine derivatives with racemic α-haloamides.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

This study demonstrated that distinct antidepressant therapies act on a common brain network. It explains previous heterogeneous findings across therapies and may be adopted to guide precision repetitive transcranial magnetic stimulation.

Molecular bilayer crystals of an organic semiconductor can exhibit metallic charge transport down to 8 K with an electrical conductivity of up to 245 S cm⁻¹, as well as charge carrier mobility values of more than 100 cm² V⁻¹ s⁻¹ at 20 K.

Improved de novo production of prostaglandin F2α at titer of 32.63 μg/L in flask cultures is developed via metabolic engineering of Yarrowia lipolytica from glucose, providing a sustainable platform to produce prostaglandins.

This manuscript integrates molecular dynamics with first-principles calculations to determine practical processing parameters for H-capturing (including metastable) precipitates in Al alloys, reducing embrittlement by 78%.

Multimodal immune profiling of ART pregnancies reveals systemic immune hyperactivation in gestational diabetes, characterized by activated CD8⁺ T cells, altered immune repertoires, and inflammatory signaling driven by FOS/JUN and KLF6.

Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuropathy.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

T follicular helper (Tfh) cells contribute to systemic autoimmunity. However, their involvement in the pathology of lupus nephritis (LN) remains unexplored. Here, by combining single-cell analysis of LN patient tissues and humanized mouse models, the authors show that mesangial cell-derived lactate regulates Tfh cell differentiation in LN by promoting Bcl6 lactylation and subsequent stabilization via K6 and k-29-linked polyubiquitination.

E3 ubiquitin ligase HRD1, a core component of the ER-associated degradation (ERAD) pathway, is essential for the TLR3-mediated innate immune response. HRD1 catalyzes polyubiquitination of TLR3 at lysine 813, which promotes its trafficking to endolysosomes and enables its proteolytic cleavage and functional activation.

Liang et al. estimate the prevalence of text modified by large language models in recent scientific papers and preprints, finding widespread use (up to 17.5% of papers in computer science).

In this work, a scenario-adaptive hierarchical optimisation framework is developed for the design of hybrid energy storage systems for industrial parks. It improves renewable use, cuts energy costs and carbon emissions, and offers a scalable pathway for the low-carbon energy transition of these parks.

Hanging Coffins were a mortuary tradition practiced in southern China and Southeast Asia. Here, the authors show that different groups of ancient Hanging Coffin practitioners are genetically related, and that they are ancestors of present-day Bo people.

The combination of plasmon-mediated electron enrichment and a continuous-flow reactor overcomes key challenges in selective methane oxidation, achieving a methanol production rate of over 6.5 mmol·g-1·h-1 with the selectivity of 100% and sustained stability over 100 h under ambient pressure.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Kumazawa, Xu, Wang and colleagues identify nuclear egress as the mechanism by which cytoplasmic chromatin fragments relocate from the nucleus to the cytoplasm in senescence. They link inflammation to metabolism by showing this egress is regulated by AMPK and metformin.

Dual atom catalysts promise efficient and durable chemical conversion but are difficult to stabilize at high temperatures. This study develops a temperature stable a copper–nickel dual atom catalyst achieving near-equilibrium CO₂ conversion.

Here the authors report that genetic or pharmacological inhibition of phosphoglycerate kinase 1, an enzyme involved in glycolysis, attenuates acute kidney injury in mouse models of acute kidney injury via inhibition of ferroptosis.

The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.

Conventional doped spiro-OMeTAD hole transport layer often leads to poor device operational stability. Here, the authors employ light to generate protons from bistriflimide dopants in the precursor solution to increase conductivity, achieving efficiency of 20.95% in perovskite solar modules.

Dysregulation in the proteasome pathway contributes to the pathogenesis of head and neck squamous cell carcinoma (HNSCC). Here the authors identify that Casein kinase 2 (CK2) mediates phosphorylation of Proteasome activator 28 subunit gamma (PA28γ), which promotes tumor formation and progression in HNSCC mouse models.

In this study, the authors present that deep brain stimulation of lateral hypothalamic area activates a hypothalamic-pontine-spinal pathway, promoting locomotor initiation and functional recovery after spinal cord injury in mice.

Zhu and colleagues identify GREMLIN1 as an FGFR1 ligand that promotes plasticity and castration resistance in prostate cancer through regulation of MAPK signaling, and show that anti-GREMLIN1 antibody therapy synergizes with androgen deprivation.

Prostate cancers (PCa) are characterized by an immunosuppressive tumor microenvironment. Here the authors identify a subset of iron-loaded cancer-associated fibroblasts secreting myeloid cell-associated proteins and driving immunosuppression in PCa.

Zhu and colleagues show that a subpopulation of spleen-derived fibroblasts secrete Gremlin 1, which suppresses chronic myeloid leukemia progression by inducing leukemia stem cell apoptosis through the BMP signaling pathway.

Fibers derived from non-silk proteins hold potential for various biomedical applications, but mechanically-balanced and highly-biocompatible regenerated protein fibers are elusive. Here, the authors report an entanglement-reinforced strategy to fabricate keratin/albumin bio-fibers that show high strength and toughness, along with favorable biocompatibility, degradability and immunocompatibility.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Hydrogels can be integrated into skin bioelectronics, though balancing stability, mechanical properties, and breathability remains challenging. Here the authors design a crosslinked organohydrogel using a solvent replacement strategy integrated into on-skin sensors.

Initially anode-free sodium batteries promise high energy density but suffer from poor rate and low-temperature capability. Here, authors introduce a fluorinated sodiophilic interphase (BiF3@Al) which enables fast Na plating/stripping, demonstrating extended lifetime under harsh conditions.

This study presents a multifunctional sensor based on Te nanowires that utilizes the thermo-piezoelectric effect to achieve simultaneous sensing of strain, strain rate, and temperature.

Understanding the behaviour of magnetic flux ropes in the Sun is crucial for explaining solar phenomena such as flares and space weather. Exploiting the high resolution available in the 1.6 m New Solar Telescope, Wang et al.capture the evolution of a flaring twisted flux rope in the low solar corona.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

SN16X is upregulated in mouse hypertrophic hearts and accelerates AngII-induced cardiac hypertrophy via enhancing EGFR recycling and transactivation.

Epstein-Barr virus is associated with increased cancer risk. Here, the authors analysed two population-based prospective cohorts in Southern China to examine the association between increased seropositivity and the risk of multiple cancer types.

PINK1/Parkin-mediated ubiquitin-dependent mitophagy is a key regulator of browning in inguinal white adipose tissue (iWAT). Here, the authors report that PNPLA7, an Endoplasmic Reticulum and mitochondria-associated membrane (MAM) protein, inhibits browning of iWAT by promoting PINK1/Parkin-mediated mitophagy upon cold challenge or adrenergic receptor agonist treatment.

Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development.

PCBP2 is elevated in AD and forms condensates that sequester mitochondrial proteins and RBPs, disrupting mitochondrial function and the NMD of BACE1 mRNA, alongside amyloid deposition. The small molecule, CN-0928 mitigates AD pathology by inhibiting PCBP2 condensation.

Maintaining facial warmth and humidity while ensuring adequate oxygen intake in cold environments is challenging for facial masks. Here, the authors design a MetaMask that recovers heat and moisture from exhaled air to warm inhaled air to 26.2 °C in a − 20 °C environment, while maintaining sufficient oxygen levels.

Locksley and colleagues describe a nutrient-sensing circuit in the small intestine. Upon feeding, TSLP production from fibroblasts is increased in a GLP-2-dependent manner, resulting in increased ILC2 activation and tuft cell hyperplasia, thus linking food intake with ILC2 activation.

In the dose-expansion cohort of this phase 1b trial, the EGFR×HER3 bispecific antibody–drug conjugate BL-B01D1 given to patients with metastatic esophageal squamous cell carcinoma led to encouraging clinical response rates, which need to be confirmed in larger efficacy trials.

The roles of liver-specific genes in hepatocellular carcinoma (HCC) remain to be explored. Here the authors report that PGRMC1, localized to the endoplasmic reticulum (ER) membrane, functions as a tumor suppressor in HCC by inhibiting c-Myc protein translation via activation of PERK independent of ER stress.

Nasal colonization by Staphylococcus aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.