Search

This study maps a spatiotemporal atlas of zebrafish cerebrovascular development, linking genes and cells to 3D vascular architecture. It reveals how vessel networks form and identifies key genes essential for blood-brain barrier integrity.

Scalable fabrication of perovskite films for large-area solar cells remains a critical challenge. Jin et al. identify the solvent-precursor interaction time as a crucial, yet overlooked, kinetic parameter controlling crystallization and propose a protocol for manufacturing high-quality perovskite films.

Papaya is a trioecious species with XX females, XY males, and XY^h hermaphrodites, and the combination of Y and Y^h chromosomes is lethal. Here, the authors identify the degeneration of the YY lethality gene on the Y chromosome as the causal balancing lethal factor that reenforces dioecy and stabilizes balanced sex ratios.

Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer metastasis. Here, the authors reported a single-cell mechanophenotyping chip that screens deformable CTCs to reveal the hematogenous metastatic potential of bacteria-infected breast cancer.

Solid additives are typically used for improving morphology and efficiency in organic solar cells (OSC). Here, the authors present 3-AR, which optimizes the active layer morphology in all-small-molecule OSCs through selective interactions, achieving a PCE of 18.43% (certified 18.16%).

The mechanism of transitions in sex determination systems are often poorly understood. This study looks at the amphioxus Branchiostoma belcheri, and finds repeated transpositions of the gene tesD have created new sex-determining regions, driving turnover of the sex determination system.

Protein kinases contribute to hepatocellular carcinoma progression and immune evasion. This study identifies SPAK as a key driver of oncogenesis and immune exhaustion, showing that SPAK inhibition synergizes with anti-PD-1 therapy to enhance antitumor efficacy.

Distributed multiparameter quantum metrology allows to probe multiple spatially distributed parameters across networked quantum systems. Here, the authors demonstrate distributed multiparameter quantum metrology in a modular superconducting quantum processor network.

Signal transduction from extracellular to intracellular artificial cells is essential for autonomous artificial cells. Here the authors reconstitute a G protein-coupled receptor (GPCR) signaling pathway in an artificial cell to regulate downstream glycogen metabolism.

Aortic aneurysm and dissection are lethal vascular diseases lacking effective medical therapy. Here the authors show that calcium channel blocker use increases AAD risk, worsens disease progression in models and patients, and may impair post-repair outcomes, warranting caution in at-risk hypertension.

Prostate cancer incidence and mortality rates vary across males from diverse populations. Here, the authors perform a proteome-wide association study across different populations and establish population-specific genetic prediction models.

Emu3 enables large-scale text, image and video learning based solely on next-token prediction, matching the generation and perception performance of task-specific methods, with implications for the development of scalable and unified multimodal intelligence systems.

CrPS₄, a 2D van der Waals A-type antiferromagnet, is shown to exhibit ideal characteristics of Stoner–Wohlfarth antiferromagnets, such as ferromagnet-like binary switching rather than layer-by-layer flipping as in other 2D A-type antiferromagnets.

The role of protein UFMylation in cancer remains to be understood. Here, the authors show that UFM1-specific ligase 1 and AKT positively regulate each other through UFMylation and phosphorylation, facilitating lipid synthesis and breast tumor growth.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

The method for separating Cl₂ based on the Bernoulli principle enables efficient electrochemical chlorine evolution under universal pH conditions in a three-phase system. This enables assembly of a membrane-free system that can resist the influence of pH changes in the electrolyte.

This study reveals that the TRPC3 channel is essential for HPV-driven cervical cancer. TRPC3 promotes malignant transformation by regulating the RASA4/MAPK pathway and EMT. Targeting TRPC3 could be a new therapeutic strategy.

Bicyclic peptides targeting integrin are promising drug candidates, yet achieving high selectivity for specific integrins remains challenging. Here, the authors design RGD-containing bicyclic peptides with a tryptathionine bridge, demonstrating that peptide 5j selectively targets integrin αvβ3, and induces αvβ3-targeted cytotoxicity by drug-peptide conjugates.

Intra-ligand charge transfer (LCT) in Cu4I4 cubes is effectively strengthened to make LCT featured excited states reversely lower than cluster-centered quenching states, resulting in electroluminescent external quantum efficiency beyond 35% and record-high 100% exciton radiation.

Eleutheroside E is a natural compound that protects hearing from cisplatin damage, working by suppressing the MAPK/NF-κB/NLRP3 pathway and pyroptosis. The antitumor efficacy of cisplatin was not reduced under the presented experiment condition.

Ethylene is involved in the regulation of multiple plant growth and developmental processes. Here, the authors use a combination of genetic, molecular, and biochemical approaches to demonstrate that ethylene signaling plays a critical role in promoting branch formation while inhibiting tendril development in cucumber.

Microbial consortia offer advantages over single strains for the remediation of environmental co-contamination. Here, the authors introduce an Degrader-Helper-Potentiator Consortium framework to design synthetic microbiomes that enhance the remediation of environmental co-contamination.

A counterintuitive mass effect in the quantum tunneling of the HNCO^{• −} anion is reported: the cis-to-trans isomerization is driven by heavy-atom carbon tunneling rather than hydrogen tunneling and occurs more rapidly than electron detachment tunneling from HNCO^{• −} to neutral HNCO.

Aberration of chromatin organisation is linked to cancer progression and cancer cell plasticity. Here, the authors investigate changes in chromatin state during the transition of cancer cells to cancer stem cells and, using a CTCF-cohesin contact reporter CRISPR screen, identify TLK2 as a driver of plasticity via regulation of chromatin loop formation.

Despite the global spread of the mpox virus, the long-term durability and breadth of infection-induced immunity are not fully understood. Here, the authors analyze MPXV-specific immune responses up to 18 months post-infection, revealing robust cellular immunity and cross-neutralization among orthopoxviruses, which inform reinfection risks and vaccine development strategies.

Lithium metal batteries are restricted by their low safety and poor electrochemical performance. Here, authors present a flame-retardant electrolyte with weakly coordinating dichloroalkane diluents, demonstrating application potential in safer lithium metal batteries in the −60 to +60 °C temperature range.

The residual methylammonium cation from additives compromises the operational stability of formamidinium lead iodide-based solar cells under thermal/light stress. Here, authors introduce MASCN to enhance film formation in ethyl acetate antisolvent and achieve efficiency of 26.1% for stable devices.

Here, the authors propose a high-capacity encrypted sound hologram mechanism to enhance the channel capacity and information security based on a multiplexing metasurface with orbital angular momentum and frequency serving as two physical keys.

Fibroblast growth factors (FGFs) are involved in renal pathophysiology. Here the authors use genetic models to show that podocyte FGF4 is protective of diabetic kidney disease progression, and that treatment with recombinant FGF4 reduced renal injury and fibrosis in diabetic mouse models.

Photocatalytic oxygen reduction reaction to produce H₂O₂ awaits in-depth knowledge for the design of active photocatalysts. Here, the authors identify that surface indium vacancies are the key to opening the activity of In₂S₃ for H₂O₂ photosynthesis.

Spatially resolved transcriptomic, metabolomic and proteomic analyses of human liver samples highlight the role of lipid-associated macrophages in metabolic dysfunction-associated steatotic liver disease.

Designing organic semiconductors for ductility and charge transport properties is a challenge. Here, the authors report a family of deformable high performance polymer semiconductor blends using hydrogenated polyisoprene.

Limited improvement of systemic therapy has been achieved in first line treatment for advanced Biliary tract cancer (BTC). In this randomized phase 2 trial on BTC, the combination of sintilimab, anlotinib, and gemcitabine/cisplatin demonstrated an improvement in progression - free survival (PFS) and objective response rate (ORR) while reducing the risk of disease progression compared to chemotherapy monotherapy.

Here, the authors develop an integrated mass spectrometry-based strategy that allows metabolic biomarker discovery based on nanoliter-scale biofluids in seconds. Biomarkers of diabetic cataracts are detected in trace ocular fluids with high diagnostic performance revealed to have and anti-cataract activity.

High voltage layered oxide cathodes are highly demanded for Na-ion batteries, but they are plagued with structural instability. Here, authors enabled a high voltage K_xNa_5-xV₁₂O₃₂ cathode with reinforced V 3d–O 2p hybridization and V 3d–orbital electron delocalization upon K substitution, translated to enhanced V ⁵⁺/V⁴⁺ with improved cycling performance.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Wang and colleagues report the clinical results and immunological correlates of a phase 2 clinical trial of cryoablation plus lenvatinib and sintilimab in persons with advanced or metastatic intrahepatic cholangiocarcinoma.

Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy, the authors show that TAs bind to the 5′ untranslated region of their target transcript to position mitoribosomes for initiation.

SPFH proteins oligomerize with distinct stoichiometries in all kingdoms of life. Here, Gao et al. determine cryo-EM structures to elucidate the compositions of the ER-resident Erlin and the mitochondrial prohibitin SPFH complexes implicated in organellar protein quality control.

Developing robust catalysts for enhanced proton transfer brings both promise and challenges to oxygen production. Here, the authors report a strong bonding strategy to produce a sulfonic-group-grafted oxygen evolution catalyst, enhancing proton transfer and accelerating reaction kinetics.