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Adipose CoA handling is critical for lipid metabolism and homeostasis. Here, the authors identify TMEM120A as an ER-resident CoA binding protein enriched in adipocytes that promotes fatty acid recycling to support energy metabolism and limit lipotoxic stress, while its loss leads to adipose inflammation and metabolic dysfunction under high-fat diet conditions.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Fluorine-containing binders in battery dry electrode processing raise environmental concerns regarding restrictions on per- and polyfluoroalkyl substances. Here, authors show that a fluorine-free binder, Parafilm, can be an alternative to enable primer-free high-loading electrodes with stable cycling for sustainable lithium-ion batteries.

A disc device integrating chromatography, centripetal liquid transfer and bead-based vesicle capture enables extracellular vesicle isolation and labelling, achieving high accuracy in cancer detection and tumour classification.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

Breeding crops with delayed senescence could plausibly increase grain yield. Here the authors show that variation at the rice SGR locus contributes to differences in senescence between indica and japonica subspecies and show that introgression can increase yield in an elite indica rice variety.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

This study estimates global suicide mortality trends from 1990 to 2021 and projects future rates until 2050 using a locally weighted scatter-plot smoother and Bayesian age–period–cohort models, revealing substantial declines and highlighting socioeconomic factors influencing variations across high- and low-income countries.

Anion-exchange-membrane electrolysis needs durable carbon supports, yet native defects corrode under harsh operating conditions. Here, the authors report that oxide-hybridized carbon serves as a durable catalyst support while facilitating the supply of reactant hydroxide ions.

This study reveals that the protein AKAP11 plays a crucial role in regulating neuronal signaling and synaptic function by linking PKA activity to autophagy. Loss of AKAP11 distorts compartment-specific PKA and GSK3α/β activities and impairs neurotransmission, highlighting a shared molecular pathway between bipolar disorder and schizophrenia.

Leber hereditary optic neuropathy (LHON) is caused by mtDNA mutations. Here, authors generated a mouse model with the common LHON mutation and showed that optimized TALE-like deaminases restored both phenotype and genotype via high-fidelity mitochondrial base editing.

SARS-CoV-2 infection has been linked to various persistent or new-onset health consequences, including disruption of the immune system. Here, the authors investigate the risk of new-onset allergic diseases following SARS-CoV-2 infection using data from South Korea, Japan, and the UK.

A dual-gate structure in bilayer MoS₂ FETs is reported, allowing a high carrier density by compensating for the fringing field, which holds promise for 2D semiconductor logic applications.

Methods used to date a network of marine sediment cores reveal that rapid retreat of the Ross Ice Shelf was contemporaneous with the lowering of nearby outlet glaciers, implicating warm ocean waters as a driver of Antarctic deglaciation.

The study presents a CMOS-compatible memristor-based bio-to-electrical transducer with built-in threshold-sensing functionality, demonstrated for electrochemical biosensor applications.

Respiratory complications of SARS-CoV-2 infection have been described in the acute (within 30 days) and post-acute (after 30 days) phase. Here, the authors characterise the risk of acute and post-acute respiratory complications of SARS-CoV-2 using population-based data from South Korea and Japan.

Fabrication of fully stretchable organic light-emitting diodes incorporating an intrinsically stretchable exciplex-assisted phosphorescent layer along with MXene-contact stretchable electrodes is described, demonstrating high efficiency and mechanical compliance for applications in next-generation wearable and deformable displays.

Using propensity score matching, Kim et al. find evidence of higher short- and long-term risk of adverse neuropsychiatric outcomes in Korean and Japanese cohorts of individuals infected with SARS-CoV-2 than in the general population.

The authors identify TMEM145 as a critical protein in cochlear outer hair cells, responsible for linking their stereocilia. Mice lacking TMEM145 develop severe hearing loss at an early age, providing new insights into hearing loss mechanisms.

HMGCR is upregulated by E2F1, driving ferroptosis resistance by reducing oxidative damage triggered by T cell-based therapy. Notably, targeting HMGCR restores ferroptosis sensitivity in immune-refractory tumors, enhancing response to PD-1 blockade as well as adoptive T cell transfer therapy.

Dual atom catalysts promise efficient and durable chemical conversion but are difficult to stabilize at high temperatures. This study develops a temperature stable a copper–nickel dual atom catalyst achieving near-equilibrium CO₂ conversion.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cataloguing Nt-arginylated proteins is prone to false positives. Here, the authors use MS-based fine-tuned LLM models with molecular proxies-physically identical yet known false positives-to discriminate true sites. They further track the modifications over time using prediction-based targeted MS.

Accurate prediction of surgical outcomes is essential for selecting treatment plans and ensuring patient satisfaction in corrective jaw surgery (orthognathic surgery). Here, the authors present and validate GPOSC-Net, a generative model for orthognathic surgery planning, to predict surgical movement and synthesize post-operative cephalograms from pre-operative data using a diffusion model.

Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.

Solid electrolytes are key to safer, high-energy batteries. Here, authors show that divalent-anion-driven framework regulation in Zr-based halides tunes the lattice and boosts Li⁺ transport, offering a universal design principle for advanced halide electrolytes.

Lee et al. analyse clinical, behavioural, and MRI features in patients with temporomandibular disorders to identify predictors of chronic pain. Using machine learning and deep neural networks, authors develop models that accurately predict chronicity based on jaw joint damage, bruxism, sleep disturbance, and symptom duration.

Lithium-ion battery cathode lifetime is limited by large expansion and contraction during cycling. This study uses electrochemical activation to suppress collapse in LiNi_0.9Mn_0.1O₂ cathodes, achieving improved capacity and cycle life.

Small cell lung cancer (SCLC) is aggressive with limited therapeutic options. Here, authors find that loss of CRACD induces neuroendocrine plasticity and immune evasion and suggest manipulating the CRACD-EZH2-MHC-I axis as a potential therapeutic strategy for SCLC.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

The genetic link between placenta function and congenital heart defects has been established, though the cellular mechanisms underlying this connection is less clear. Here they show that PIBF1 regulates syncytiotrophoblast fusion and that loss of PIBF1 also negatively impacts heart development, providing a potential link between the development of these two organs.

The immune system undergoes significant changes with age. However, protein level characterization of these age-associated changes is limited. Here, the authors develop a machine learning (ML) model to predict changes in immune cell composition across different age stages based on CyTOF data on mouse CD45+ spleen cells and test the reliability of the ML model in predicting biological age using an obese mouse model, supporting the applicability of this tool to identify disease-related immune senescence.’

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Ultralow-power ferroelectric field-effect transistors are used to achieve low-power NAND flash memory, overcoming the trade-off between multi-level capability and power efficiency and paving the way for next-generation storage memory.