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Eukaryotic Fanzor proteins are compact and advantageous for delivery, but their activity remains limited. Here, the authors engineer an improved Fanzor2 system (evoMmeFz2) using structure-guided and AI-assisted strategies to enable efficient exon skipping in a Duchenne muscular dystrophy model.

Metal–ligand synergistic catalysis remains underexplored in single-atom systems. Here, inspired by homogeneous pincer complexes, the authors construct Pd(II)–N₄ sites on carbon nitride, enabling highly selective photocatalytic semi-hydrogenation of alkynes.

Here they establish an NTR-based genetic ablation tool in axolotls to investigate the function of specific cells. They use this system to demonstrate the capacity of ependymoglial cells for central nervous system regeneration.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

The authors create a room-temperature super relaxor critical state in a lead-free ceramic, delivering dual-high recoverable energy density and efficiency by residing at a crossover between dynamic and static/frozen polar states.

Conventional amides electrosynthesis methods confine reactions to solely electrochemical reduction or oxidation processes, resulting in low amides yield rates. Here, the authors report a tandem electrolyzer that couples cathodic nitrate reduction with anodic ethanol oxidation to produce acetamide.

An extreme barocaloric effect in NH₄SCN aqueous solutions is enabled by pressure-induced dissolution and precipitation, but without using a separate heat-transfer liquid.

This work identifies the key electron-transfer limitation in electrocatalytic contaminant removal and delivers a dual-function strategy that boosts efficiency by combining molecular enrichment with precisely controlled charging-discharging.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Shoot branching is critical in determining soybean yield. Here, the authors report natural variation of Dt2 in controlling soybean branching number and the interaction of Dt2 with GmAgl22 and GmSoc1a to activate transcription of GmAp1a and GmAp1d.

A body-induced electroluminescence device enables three-dimensional finger tracking, providing a versatile platform for human–machine interaction that senses motion both on and above the device surface.

Rapeseed production is often threatened by drought stress. Here, the authors report transcription factor BnaA9.NFYA7 negatively regulates rapeseed drought tolerance through ABA signal transduction pathway via feedback inhibition of the expression of BnaABF3/4s-related genes.

Electrochemical capacitors are limited by low capacity. Here, authors report that the increased offset potential from potential of zero charge electrochemically drives the continued partial desolvations in carbon nanopores, leading to largely increased electric double-layer capacitance and capacity.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Optical heterostructures have potential in integrated photonics and optoelectronics but are challenging to prepare in single-component systems. Here, the authors report an intrinsic optical heterostructure in an organic nanosheet, with enhanced fluorescence in an inner zone.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

Intramolecular coupling of extended biphen[n]arenes is developed to yield cycloparaphenylenes (CPPs). The modular nature of biphen[n]arenes makes it possible to customize CPP structures, which permits tuning of their photophysical properties. The syntheses are short and excellent yields are achieved. Moreover, postsynthetic functionalization is possible.

This study identifies 245 genetic loci associated with head-to-body ratios using 38,202 bone density scan images from the UK Biobank, revealing genetic links to skeletal and brain development, disease susceptibility, and human evolutionary adaptation.

The paper demonstrates a ferroelectric photosensor array that integrates image memorization, low-level processing, and high-level computing. It uses dynamic and switchable photovoltages to perform image tasks, leveraging the bulk photovoltaic effect for enhanced precision and reliability.

Microgravity triggers carotid artery aging via SREBP1. This lipid regulator remodels chromatin by boosting acetyl-CoA, silencing contractile genes while activating aging pathways. Targeting SREBP1 blocks senescence, revealing a therapeutic strategy for spaceflight-associated vascular remodeling.

Achieving high output-power-density in Gallium-nitride transistors is challenging due to high thermal resistances and thick nitride layers. Here, the authors propose ion-implantation on silicon-carbide substrates, achieving high performance and reduced thermal resistance.

There is an unmet medical need for endometrial cancer patients with mismatch-repair proficient disease. Here, the authors report the primary analysis of the FRUSICA-1 phase Ib/II trial evaluating fruquintinib plus sintilimab in this population, showing an ORR of 32.7%, a median PFS of 8.6 months, and manageable toxicity.

Metastatic cancer cells rely on metabolic flexibility to survive. Here, the authors show that metastatic breast cancer cells use lactate for mitochondrial oxidation via the CD147/MCT1/LDHB complex to sustain stemness and promote metastasis.

A tension-modulated DNA origami-based nanosensor, compatible with bulk biochemical analysis in cell lysates, is used to assess the force-induced interaction of proteins involved in cellular mechanotransduction.

This study elucidates nanoscopic strain evolution in single-crystal Ni-rich positive electrodes, demonstrating that mechanical failure results from lattice distortions, and redefines the roles of cobalt and manganese in battery cycling stability.

Nonalcoholic fatty liver disease (NAFLD) has limited dietary treatment options. Here, the authors show that torularhodin, a microbial carotenoid, alleviates NAFLD by enriching Akkermansia muciniphila and promoting adenosylcobalamin synthesis, which reduces ceramides via HIF-2α inhibition.

A study shows that variations in carbon allocation between starch and lignin biosynthetic pathways among cassava cultivars are regulated by specific metabolic flux step alterations and demonstrates MeCOMT8’s critical role in lignin synthesis.

Electrical doping and charge transfer in 2D antiferromagnet CrSBr reversibly switch its magnetic state, enabling gate-tunable spin valves and ultralow-power spin control without ferromagnetic contacts, advancing fully electrical 2D spintronics.

The regulatory roles of structural variations (SVs) in transcriptional networks and agronomic traits of tea plants are largely unexplored. Here, the authors assemble the pangnome from 22 representative tea accessions and their wild relative and reveal SVs driving gene expression alteration and agronomic traits diversification.

Authors report cryo-EM structures of AL amyloid fibrils from the kidney of a male patient with renal AL amyloidosis. Comparison to previous heart-derived fibrils reveals variations linked to sequence differences and insights into fibril assembly and organ tropism in AL amyloidosis.

Genomic, transcriptomic and metabolomic analyses from a population of 295 diverse sweet-corn inbred lines provide insights into kernel quality formation mechanisms and the divergence of sweet corn and field corn.

Converting carbon dioxide into valuable multi-carbon products remains challenging under acidic conditions. Here, the authors develop a covalent organic framework–modified copper nitrate catalyst that enables stable ethylene production at high current densities.

A natural variant of RCN2 enhances nitrogen assimilation and grain yield in rice by restricting chromatin loop extrusion and competitive interaction with the OsSPL14–SLR1 regulatory module.

A dual interfacial hydrogen-bond passivation strategy and a hybrid copper–iodide are used to fabricate deep-blue light-emitting diodes with excellent external quantum efficiency and lifetime.

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

The role of lysine crotonylation (Kcr) in MASLD pathogenesis remains unclear. Here, the authors identify a PCAF/SIRT7-IDH1 Kcr axis that ameliorates hepatic steatosis by boosting TCA cycle activity, uncovering a new mechanism and therapeutic target for MASLD.

KN046 is a bispecific antibody targeting PD-L1 and CTLA4. Here the authors report the results of a phase II trial of KN046 combined with lenvatinib in patients with advanced hepatocellular carcinoma.

High-temperature resistant dielectric polymers are promising for electrostatic capacitors, though often have poor mechanical strength or energy storage. Here the authors design a hydrogen bonding polymer balancing mechanical and dielectric properties.