Search

A joint analysis of sugars and amino acids in the Orgueil meteorite, a proxy for asteroids Bennu and Ryugu, reveals multiple biologically relevant sugars, including ribose, supporting efficient sugar formation in space and a richer prebiotic delivery to early Earth.

Alternative splicing greatly expands the transcriptomic and proteomic diversity in vertebrates. Here, the authors develop a machine-learning tool to identify functional splicing events during hematopoietic cell differentiation, revealing new regulators of hematopoiesis.

A streamlined blood test using mass spectrometry improves measurement of amyloid-β for early Alzheimer’s disease diagnosis, requiring less sample volume and reagents while maintaining high accuracy, sensitivity and strong agreement with brain imaging.

Asexual-to-sexual switching underpins malaria transmission. Prajapati et al. identify an AP2-G loss-of function mutation and use it as a genetic tool to show that GDV1 is essential for initial ap2-g activation and sexual commitment initiation.

The study shows how inherited weak zones determine whether transpression produces pushups, duplexes, or parallel faults. 3D models offer insights into the deep processes that drive deformation and seismic patterns in the Caribbean and Levant.

Irregular terrains challenge users of classic prosthetic feet. Here, the authors introduce an adaptive prosthetic foot that equalizes ground contact pressure and reduces compensatory strategies and gait asymmetries compared with a traditional carbon fibre foot.

Climate change can alter when and how animals grow, breed, and migrate, but it is unclear whether this allows populations to persist. This global study shows that shifts in seasonal timing are key to helping vertebrate species maintain population growth under global warming.

Xeno-learning uses preclinical data from one species to boost the performance of neural networks applied to another species when exploring physiological responses.

Plant traits drive ecosystem dynamics yet are challenging to map globally due to sparse measurements. Here, the authors combine crowdsourced biodiversity observations with Earth observation data to accurately map 31 plant traits at 1 km² resolution.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Chronic stress disrupts the brain vasculature and contributes to mood disorders, but mechanisms of resilience remain unclear. Here, the authors show that enriched environments increase astrocytic Fgf2 to prevent stress-induced vascular alterations and depressive behavior with relevance to human depression.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

Moral-Sanz, Fernández-Carrasco and colleagues identify senolytic properties of sea anemone-derived pore-forming toxins, with selectivity mediated by senescence-associated lipid profiles. An optimized senotoxin improves the efficacy of chemotherapy in mouse models.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms and the long-term evolutionary dynamics of cis-regulatory elements in animals.

Time-resolved serial femtosecond crystallography at X-ray free-electron lasers is a powerful approach for studying macromolecular dynamics, but its widespread use is limited by high sample consumption. Here, the authors introduce a segmented-droplet mix-and-inject strategy at the European XFEL that reduces sample consumption by up to 97% while preserving the data quality required for time-resolved structural studies of the enzyme NQO1.

Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.

Van der Waals two dimensional materials made of graphene and covalent organic frameworks have potential for advanced electronics applications and a fundamental understanding of the formation process of these materials is desirable. Here, the authors revealed the main aspects that influence the twisted stacking growth of pyrene diboronic acid covalent organic frameworks on graphite with a hybrid molecular mechanics force field.

NiPS₃ is a van der Waals antiferromagnetic semiconductor where the exciton formation is strongly influenced by the magnetic ordering. Previous studies have been limited to magneto-optical approaches, but here, Lebedev, Gish and coauthors succeed in making field effect transistors that operate below the Néel temperature and observe an ultranarrow electroluminescence with a high degree of linear polarization.

Detection of hot intracluster gas in SPT2349−56 with the Atacama Large Millimeter/submillimeter Array provides new insights into early cluster formation.

Analyzing data of the Mexican Biobank project, a new study finds regional differences in clinically relevant genetic frequencies and presents MexVar, a publicly accessible resource designed to support ancestry-informed genetic testing.

Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

Alström syndrome (AöS) is a rare genetic disorder characterized by metabolic problems. Here, the authors show that in AöS models, defects in cilia and autophagy lead to ACBP accumulation, which drives obesity. An anti-ACBP antibody reduces weight gain and metabolic dysfunction, highlighting ACBP as a therapeutic target for this ciliopathy.

Here the authors perform longitudinal sampling of lymphoid organs along with fate mapping and matched single-cell RNA sequencing and TCR sequencing to define the developmental dynamics of follicular regulatory T (T_FR) cells. They find that T_FR cells undergo clonal expansion and progressive differentiation in a process that requires follicular helper T cells.

Exploring the quantum nature of gravity requires systems that balance quantum control and gravitational interaction, most plausibly within the microgram-to-milligram mass range. Here, the authors develop a 1-milligram torsional pendulum operating at 18 Hz, achieving unprecedented cooling to 240 microkelvins, positioning it as a promising platform toward probing quantum gravity interactions.

Water interactions with cerium dioxide surfaces are central to hydrogen production and catalytic redox reactions. Here, atomic force microscopy with oxygen-terminated probes and first principles calculations provide detailed mechanistic insight of the interactions at play.

Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and reduces neuroinflammation, identifying a possible target for multiple sclerosis treatment.

This study examined auditory predictive processing at the single-neuron level in the inferior colliculus of genetic and environmental rat models of autism. Authors identified sex- and etiology-dependent alterations across auditory midbrain divisions, revealing early differences in sensory computations.

Colloidal suspensions are known to display a glass transition. Now, insights into this transition, via its effect on the solvent, are gained by probing the correlated motion of tracer particles in such systems.

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

Inconsistent diagnostic criteria and treatment approaches may hinder medical care and research for lipedema. Here the authors report a multi-phase Delphi study proposing consensus-based definition and management of lipedema.

Maldonado, Lopez-Hernandez, et al. use a matched case-control study to compare E. coli-infected patients with or without sepsis. Their analysis shows that the ST69 clone is associated with risk of sepsis development, and certain genetic factors such as adhesion genes papC and fdeC were associated with a protective effect.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function.

Tree ectomycorrhizal colonization in aridity regions is supported by microbial cooperation, where bacteria attach to fungal hyphae and reduce inhibitory soil metabolites, suggesting a microbiome-based strategy for tree restoration.

Standard of care in patients with unresectable stage III non-small cell lung cancer (NSCLC) is concurrent chemo-radiotherapy followed by immunotherapy. Here, the authors report a phase II trial investigating induction chemo-immunotherapy (atezolizumab, carboplatin and paclitaxel) followed by concurrent chemoradiotherapy and immunotherapy maintenance in patients with stage III NSCLC.