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Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

This study presents an HDB (horizontal diagonal band) – mPFC (medial prefrontal cortex) – thalamus circuit and the cholinergic signaling in mPFC Foxp2⁺ neurons in modulating sensory and affective pain in male mice.

This study reports that genomic signatures composed of the loss of pluripotency inhibitors, expansion of pluripotency activators and maintenance of an epigenetically permissive state contribute to the plantlet formation in Kalanchoe.

This work proposes an innovative method of 3D skeleton preconstruction-infiltration filling to construct a 3D pristine graphene@pyrocarbon skeleton in AZ91D, improving electromagnetic interference shielding and load bearing of the composites.

The Huayuan biota exhibits extraordinary biodiversity, illuminating the impact of the Phanerozoic mass extinction around 513 million years ago and offering critical insights into the transformation of global ecosystems in the early Cambrian.

The cellular makeup of the primate cochlea, crucial for hearing, remains poorly understood. Here, authors show a detailed map of primate cochlear cells, revealing both conserved and species-specific features.

Heart failure affects millions worldwide with limited treatment options. Here, the authors develop a biodegradable, self-powered vagus nerve stimulator that attenuates cardiac damage at different disease stages without requiring battery replacement or surgical removal.

Here the authors show a general method to make alkoxide-based network-forming glasses with tunable properties by combining titanium, zirconium and boron-based nodes, multi-dentate alcohol linkers and mono-dentate alcohol modulators.

The structure of layered oxides dictates their properties as positive electrodes in sodium-ion batteries, but its rational design remains challenging. Here, authors employ electronegativity and configurational entropy as a design descriptor to guide the synthesis of a sodium-deficient layered oxide with an O3 stacking sequence, rendering good thermal and air stability.

Dissipative many body systems provide quantum-enhanced sensitivity to external near gap-closing points. Here, the authors demonstrate record sensitivity in a Rydberg-atomic platform in correspondence of folded hysteresis trajectories under external microwave driving

The mechanical properties of inorganic solid electrolytes for Li batteries are typically characterised by a high Young’s modulus above 15 GPa and hardness above 1 GPa. Here, authors develop a cost-effective and mechanically compliant inorganic solid electrolyte, with reduced Young’s modulus and hardness of 1.41 and 0.22 GPa, respectively, for practical all-solid-state Li batteries.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Tuning the interfacial structure of silver nanoclusters via steric hindrance modulates their photoluminescence. Locking the ligand shell endows the clusters with room-temperature photoluminescence, thereby enabling atomic-level design of optical devices.

Spatial omics maps molecular features to tissue architecture, but it often misses rare cell populations. Here, the authors present GARDEN, a graph-based framework that detects pathogenic cells and regions across spatial omics, enables 3D tissue reconstruction, and reveals immune and regulatory mechanisms in several diseases.

Soil life relies on microbial nutrient exchange to maintain ecosystem balance. This study shows that cobamide-producing microbes act as essential connectors in soil food webs, supporting host health and highlighting cross-kingdom links central to One Health.

Hepatokine FGL1 mediates liver-kidney crosstalk in renal fibrosis. Upregulated by circulating inflammatory cytokines post-injury, it binds ALK5 to potentiate TGF-β signaling and promotes fibrotic progression, presenting a promising target for CKD.

The inter-system crossing induced by selenium may undesirably enhance formation of triplet excitons in non-fullerene acceptors, leading to increased non-radiative losses. Here, the authors introduce achiral N-alkyl substituents, achieving maximum efficiency of 20.4% for ternary organic solar cells.

Metabolite signatures were identified for subtypes of dietary carbohydrate, including added sugar, whole grain and refined grain, and showed different associations with type 2 diabetes, providing an objective measure of dietary risk.

Quantum low-density parity-check error correction codes are anticipated to deliver high performance, but require long-range qubit–qubit interactions. Two of these error correction codes have now been successfully implemented on a superconducting device.

Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention.

Aqueous zinc-ion batteries are promising for sustainable energy storage but challenged in low temperatures. Here, authors develop a gradient chaotropic ionic liquid-based aqueous electrolyte design that enables dendrite-free operation and robust low-temperature performance (to −40 °C).

Short-circuiting during fast charging through lithium dendrite intrusion into electrolytes is a major challenge in solid-state batteries. Here, using thermally annealed 3-nm-thick Ag coatings, lithium penetration into brittle electrolyte Li_6.6La₃Zr_1.6Ta_0.4O₁₂ is inhibited at local current densities of 250 mA cm⁻² due to an increase in surface fracture toughness.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

The efficient low-temperature combustion of stable alkanes remains a major challenge in catalysis. Now it has been shown that a Pt–Nb dual-atom catalyst enables propane combustion through a distinct stepwise-boosting, current-assisted atomic relay mechanism, yielding complete conversion below 200 °C and a high turnover frequency.

Anhydroicaritin-loaded mesenchymal stem cell exosomes attenuates IMQ-induced murine psoriasis-like skin inflammation and acted as a therapeutic candidate for psoriasis management.

A device for rectifying supercurrents at liquid-nitrogen temperature with high efficiency is demonstrated. This is a practical step towards implementing dissipationless electronics.

The underlying strategies to tackle A-site inhomogeneity of Rb-alloyed wide bandgap perovskites remain under investigation. Here, authors incorporate a melamine additive as a phase uniformity regulator, achieving stabilized efficiency of 33.5% for two-terminal perovskite/silicon tandem solar cells.

Morphology control of two-dimensional metastable phase nanomaterials is a core issue for catalyst design. Here, two-dimensional metastable-phase Ni hexagonal nanosheets are synthesized via a one-pot method, exhibiting competitive catalytic performance in the electrocatalytic acetone hydrogenation.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

Signalosomes amplify cellular responses, but how they avoid uncontrolled activation is unclear. The authors use quantitative super-resolution imaging and mathematical modeling to reveal optimal RIP3:RIP1 ratios that ensure precise cell death signaling.

Glycerol electro-oxidation to valuable chemicals could play an important role in sustainable chemical processes. Here the authors realize near-unity Faradaic efficiency for such reaction at an industrially relevant current density, by introducing a trace amount of copper ions to electrolytes.

Shape-changing substrates are pivotal for advancing minimally invasive, conformable bioelectronics, yet their implantation is hindered by inaccessible triggering mechanisms and complex geometric fabrication. Here, the authors report a digital 4D printing technique for fabricating customized shape memory hydrogel substrates enabling trigger-free shapeshifting with predefined onset periods.

Acidic CO₂ electroreduction enables high CO₂ utilization but suffers from competing hydrogen evolution. Here, the authors present selective CO₂ conversion on asymmetric C₃-Ni-Cl single-atom sites, which achieves carbon-efficient CO production in strong acid.

Negative refraction—light bending opposite to conventional refraction—and a hyperlens effect is observed in an excitonic system in the two-dimensional magnet CrSBr. The effect is mediated by the magnetic order of the material.

A nanoengineered, zero-volume-change, complete-sealing Li-based composite electrode, comprising multilayer reduced graphene oxide and zinc oxide, is developed, achieving Li plating/stripping Coulombic efficiencies of ≥99.99%.

Prior hypoglycemia alters the paracrine interaction between islet α and δ cells, leading to impaired counter-regulatory glucagon secretion through somatostatin hypersecretion, increasing the risk of recurrent hypoglycemia.

Cascaded nonlinear optics has long enabled advances in short-wavelength generation, but equivalent approaches for long wavelengths remain underdeveloped. Here, the authors demonstrate a chip-based lithium niobate platform that delivers tunable mid-infrared light, opening new possibilities for sensing, spectroscopy, and communications.

Antibiotic resistance is a growing global threat, yet the role of extracellular defence mechanisms remains underexplored. This study reveals that evolved extracellular polymeric substances act as a frontline shield, substantially boosting Escherichia coli antibiotic resistance, demonstrating their key but overlooked role in antibiotic resistance.

LiCoO₂ faces challenges at high voltages due to structural instability and poor thermal/hydrolytic performance of traditional lithium salts. Here, authors show stable LiCoO₂ batteries at 4.7 V using covalent fluorine-rich lithium salt, exhibiting good heat and water tolerance.

Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.

A dipolar-passivation strategy enables all-perovskite tandem solar cells with a power conversion efficiency of over 30%.

Static magnetic fields can only interact marginally with non-magnetic materials. Here, the authors show that dynamic magnetic flux can rotate non-magnetic particles and transform them into microstructures with nanoscale fibrous textures.