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The preparation of thin covalent organic framework membranes on porous substrates using conventional in situ and secondary-growth methods is challenging. Here, the authors applied a non-solvent induced phase separation-triggered in situ interfacial polymerization strategy to produce covalent organic framework-mixed matrix membranes applied to gas separation.

This study demonstrates that the reduced serum serine in patients with chemotherapy or women with poor sleep, is linked to the decline of ovarian function. Serine supplementation prevented ovarian damage in mice by inhibiting ferroptosis in ovarian granulosa cells, without affecting chemotherapy efficacy.

Transition-metal-catalyzed nitrene strategies exhibit high efficacy for intermolecular N–H insertion, but nitrene-mediated N–N coupling under metal-free conditions has rarely been explored. Herein, the authors report the selective N–N coupling using sulfilimines as nitrene precursors.

Genome evolutionary history of wild Arachis species remains unclear. Here, the authors report the origin of small chromosome A08 and genome evolution of Arachis species via comparative oligopainting and genomic analysis of A. hoehnei.

The performance of π-conjugated polymers films is limited by the short exciton diffusion lengths due to local imperfections or variations in interchain packing. Here, the authors report on large-area submillimeter-scale spherulites achieved by treating a spin-coated polydiarylfluorene film under solvent vapor annealing.

This study achieves precise atomic-scale control over ferroelectric polymer chains through facet modulation, significantly enhancing ferroelectric phase stability, thereby enabling efficient and tunable multiband electromagnetic attenuation.

This work describes a Pd−B diatomic catalyst that can selectively catalyze the photosynthesis of glycine via C−N coupling reaction between PET-derived ethylene glycol and nitrate, achieving a yield of 2.9 mmol g_cat⁻¹ h⁻¹ and selectivity of 92%.

Pan et al. report an N-Ni/NiCo@C catalyst for solar-driven photothermal methane dry reforming. Its designed structure enables a lattice oxygen-free reaction mechanism, achieving high efficiency and stability.

This study shows that excessive atmospheric nitrogen deposition can enhance methane production and emissions by impacting microbial phosphorus acquisition due to the change of N/P ratios in oxygenated surface oceans.

The integration of high-κ dielectrics with low equivalent oxide thickness (EOT) is crucial for the development of 2D transistors. Here, the authors report the low-temperature fabrication of wafer-scale HfO₂ dielectric films with sub-5-Å EOT and their application for the realization of high-performance 2D MoS₂ transistors and circuits.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

SK2 channel regulates the intrinsic excitability and firing frequency of excitable cells. Here, authors present the cryo-EM structures of human SK2 with apamin and three modulators, revealing the structural basis for activation and inhibition of SK2.

Here the authors show a general method to make alkoxide-based network-forming glasses with tunable properties by combining titanium, zirconium and boron-based nodes, multi-dentate alcohol linkers and mono-dentate alcohol modulators.

In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (before 15:00 h) experienced longer progression-free survival compared with those receiving late time-of-day infusions.

Prostate cancer incidence and mortality rates vary across males from diverse populations. Here, the authors perform a proteome-wide association study across different populations and establish population-specific genetic prediction models.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Here, the authors document the evolutionary dynamics of angiosperm pollen, using pollen morphology and time calibrated phylogeny. They identify two surges in pollen disparity in the mid-Cretaceous and Paleogene that are associated with environmental changes and important pollen adaptations.

A self-powered symbiotic transcatheter pacemaker that regenerates energy via electromagnetic induction from the cardiac motion demonstrates a month-long operation in a porcine model of arrhythmia and surpasses the critical energy condition for lifelong service.

Next-generation autonomous systems call for robust perception capabilities in diverse environments. Dun et al. report an ultraviolet-to-mid-infrared photosynapse array with 65,536 pixels and efficient in situ processing capabilities for dynamic trajectory recognition under challenging conditions.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

A van der Waals heterostructure made from atomic layers of ferroelectric CuCrP₂S₆ and ferromagnetic Fe₃GeTe₂ can offer reversible, non-volatile ferroelectric control of two-dimensional magnetism.

Earth-abundant cobalt-based catalysts have shown promise to replace iridium as anode catalysts in proton-exchange-membrane water electrolysers, but unfortunately they exhibit high degradation rates. Now, a lanthanum and calcium co-modification of Co₃O₄ is presented, in which lanthanum tunes the water–surface interactions to suppress cobalt dissolution and improve stability, while calcium leaching creates coordinatively unsaturated cobalt sites, leading to enhanced activity.

The authors find that O-GalNAc transferase 2 (GALNT2) restricts viral infection, probably through the regulation of the proteolytic processing of viral glycoproteins via its O-linked glycosylation activity, impairing virus–cell fusion.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

The fabrication of two-dimensional covalent organic framework films with uniform thickness, ordered structure and excellent semiconducting performance directly on substrates for applications in electronic devices remains challenging. Here, the authors address the challenge and produce out-of-plane oriented two-dimensional covalent organic frameworks by a Marangoni flow-aided interface synthesis method.

Dissipative many body systems provide quantum-enhanced sensitivity to external near gap-closing points. Here, the authors demonstrate record sensitivity in a Rydberg-atomic platform in correspondence of folded hysteresis trajectories under external microwave driving

While the major sinks for isocyanic acid (HNCO), a toxic atmospheric constituent emitted by biomass burning and catalytic converters in car engines, have been considered to be heterogeneous loss processes and dry deposition in the free troposphere, the role of Criegee intermediates remains underexplored. Here, using electronic structure calculations and kinetic simulations, the authors show that HNCO is highly reactive to stabilized Criegee intermediates in the atmosphere, discussing its potential role as sinks for HNCO.

Here, in a large-scale clinical trial, the authors associate gut microbiota composition and metabolic status with effectiveness of dietary fiber intervention in prediabetes, and provide a clinically applicable model to guide microbiome-targeted personalized medicine.

Wang et al. propose a 3D meta-holographic zoom micro-projector, integrating a high-resolution metasurface with a tailored liquid lens, resulting in a 3D zoom micro-projector of only 0.18 cm³, small enough to fit on a fingertip.

Low level of pyruvate kinase M2 (PKM2) activity in cancer cells is essential for the dependence on aerobic glycolysis. Here the authors show that PKM2 sulfhydration by hydrogen sulfide destabilizes the PKM2 tetramer, leading to reduced PKM2 enzyme activity and enhanced proliferation of breast cancer cells.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.

Terahertz switches that are based on a zero-change silicon-on-insulator process—and operate through the electrical control of displacement fields and tunnelling currents in the interface between polycrystalline and bulk silicon—can achieve sub-30-ps switching.

The authors show that NAT10 is upregulated with T cell antigen receptor signaling and that T cell-specific NAT10 deficiency results in diminished numbers of naive T cells, translating to an inability to mount a significant antiviral T cell response.