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Spin-crossover complexes are promising candidates for molecular bits owing to their magnetic bistability but engineering high-density bits is challenging due to cooperative switching dynamics. Here the authors modulate the cooperative dynamics of surface-confined spin-crossover complex chains.

Here they show that NONO collaborates with HOXA1 to modulate gene expression during early cardiomyocyte differentiation. This interaction facilitates activation of the Wnt signaling pathway, establishing the NONO-HOXA1-Wnt axis as a key mechanism in cardiac development.

This study reveals a hierarchical development of the brain’s structural connectome from infancy to childhood, characterized by distinct sensorimotor-association trajectories and alignment with multiple neurobiological hierarchies.

Self-amplifying RNA enables durable therapeutic expression, but its high immunogenicity and low-fidelity replication limit its use. Here, authors engineer a Norovirus-derived VPg-saRNA platform that achieves cap-independent, low-immunogenic and precise therapeutic protein expression in vivo.

In this work, Chang et al. report a thermotropic liquid additive for perovskite solar cells that enables dynamic interface management, simultaneously passivating defects and suppressing ion migration to deliver high efficiency and substantially enhanced operational stability.

Behçet’s syndrome is a chronic inflammatory disease with oral ulcers being the most common symptom. Here authors present results from a phase 2 randomized double-blind placebo-controlled clinical trial that shows that systemic low dose interleukin-2 could be safely administered to these patients, and the therapy may improve their quality of life.

This work creates a magnon-photon interface from a 2D magnetic semiconductor metasurface. It demonstrates both the static and ultrafast control of exciton polaritons with spins and coherent magnons, paving the way for spin-based photonic devices.

Genome evolutionary history of wild Arachis species remains unclear. Here, the authors report the origin of small chromosome A08 and genome evolution of Arachis species via comparative oligopainting and genomic analysis of A. hoehnei.

Phagocytes must safely remove mitochondria released after tissue injury to prevent harmful immune activation. Here, the authors show that TMEM110 preserves lysosomal function to clear mitochondrial DNA, thereby limiting organ damage and mortality after traumatic brain injury.

In patients with hypopharyngeal squamous cell carcinoma (HPSCC), resistance to the standard-of-care induction chemotherapy often occurs. Here, using longitudinal single-cell transcriptomic profiling of HPSCC samples from patients receiving induction chemotherapy, the authors identify a ZNF683-high natural killer (NK) cell population as a predictor of chemotherapy response.

Xu et al. report that inhibition of the F-box protein FBXL2 enhances HER2 expression, rendering HER2-negative breast cancer sensitive to the anti-HER2–drug conjugate trastuzumab deruxtecan.

The role of RNA-binding protein (RBP) phase separation in transcriptional regulation and its contribution to tumorigenesis remains to be characterised. Here, the authors show that RBP AKAP95 physically co-condenses with the mixed lineage leukemia 1 (MLL1) translocated fragment commonly found in MLL rearranged (MLLr) leukemia to promote leukemogenesis.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

Multi-omics and genetic models show that CGG repeat toxicity in GABAergic neurons drives FXTAS pathology and identify PRKCG as a critical modifier and potential therapeutic target.

Mechanistic modeling of sulfatide-reactive type II NKT cells reveals their role in regulating M2 polarization of alveolar macrophages through the iNKT cell–IL-10 axis, thereby alleviating lung ischemia–reperfusion injury.

Aortic aneurysm and dissection are lethal vascular diseases lacking effective medical therapy. Here the authors show that calcium channel blocker use increases AAD risk, worsens disease progression in models and patients, and may impair post-repair outcomes, warranting caution in at-risk hypertension.

The authors identify key enzymes, including four cytochrome P450s, a dehydrogenase and a sulfotransferase, that together build the core chemical scaffold of withanolides, medicinal compounds from ashwagandha with neurological and anti-cancer activities.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.

Tip-focused radiofrequency perforation enables soft, bloodless implantation of flexible electronic hairs, advancing semi-implantable electrophysiology for prosthetics and human–machine interfaces.

Engineered bacteria sense gut bleeding and secrete repair materials.

A non-invasive 40 Hz light flicker induces adenosine-mediated ischemic preconditioning, offering a potentially safe and translational approach to protect against nonarteritic anterior ischemic optic neuropathy and related ocular ischemic disorders.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Integrating computational analyses of T cell exhaustion and mitochondrial fitness atlases with in vivo CRISPR screens has identified KLHL6 as a dual-negative regulator of both exhaustion differentiation and mitochondrial dysfunction, highlighting its potential as a target to enhance anti-tumour immunity.

Wastewater treatment plants harbour extensive but poorly characterized microbial genetic diversity. Using 828 metagenomes from wastewater treatement plants globally, this study reconstructs >24,000 metagenome-assembled genomes, including >12,000 new species, providing a genome-resolved framework for understanding and engineering activated sludge functions.

Negative regulator of thermotolerance 1 (NAT1) is identified as a negative regulator of thermotolerance in rice through the NAT1–bHLH110–CER1/CER1L module. Modifying NAT1 by targeted gene editing increases wax deposition and enhances thermotolerance in rice.

Hanging Coffins were a mortuary tradition practiced in southern China and Southeast Asia. Here, the authors show that different groups of ancient Hanging Coffin practitioners are genetically related, and that they are ancestors of present-day Bo people.

Achieving stable p-type doping in MoS₂ is crucial for enabling complementary logic circuits but remains substantially more challenging than n-type doping. Here, the authors demonstrate metal-organic chemical vapor deposition growth of wafer-scale Nb-doped MoS₂ films with uniform p-type behavior, offering a thermodynamic-kinetic model for doping control, thereby advancing scalable 2D materials for low-power, flexible electronics.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Researchers identified a unique “latch bulge” in yeast mitofusin Fzo1. This fungi-specific structure allows Fzo1 to dimerize and remain locked after catalyzing GTP hydrolysis, enabling efficient mitochondrial fusion with minimal energy consumption.

Surgical tasks within tortuous and narrow lumens require interventional instruments with controllable mechanical adaptability. Here, the authors present the Helixoft microrobotic system, which enables continuous stiffness tuning and active steering of microcatheters with diameters down to 300 μm controlled by weak magnetic fields.

LipoID profiles lipid droplet interactions and identifies interorganelle regulators.

Direct observation of the Migdal effect in neutron–nucleus collisions is reported, which resolves a long-standing gap in experimental validation.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

The high prevalence of anxiety in inflammatory bowel disease patients. Here, authors show SP alleviates colitis and anxiety-like behaviors via gut microbiota and inositol by blocking microglial NF-κB and enhancing astrocytic GABAergic/Ca²⁺ signaling.

Electrocatalytic co-reduction of CO₂ and NO₃ ^- for urea synthesis is constrained by low efficiency. Here, the stable Cu^δ+ active sites, regulated by an analogous rectifying interface effect, not only enhanced the critical C-N coupling dynamics but also enabled high-performance urea synthesis.

Gao et al. realized a discontinuous orbital angular momentum metasurface holography, which enhances the channel capacity for holographic multiplexing and makes significant strides in high-security optical information encryption.

The extreme hot and dry conditions of 2023 reduced soil respiration and enhanced net forest carbon sequestration in Canada, offsetting wildfire emissions, according to satellite-based and in situ observations of CO₂ fluxes.