Search

Peritoneal metastasis remains a major clinical challenge due to the lack of effective therapeutic options. In this study, the authors present intraperitoneal programming of tailored chimeric antigen receptor macrophages (CAR-Ms) as a strategy against peritoneal metastasis.

In this Resource paper the authors provide a multiomic single-cell atlas of mouse eosinophil heterogeneity across various organs and use fate-mapping methods to look at the dynamics of residency.

Hepatitis E virus is a leading cause of acute viral hepatitis and antibodies can persist for years post-infection. Here, the authors quantify the protective effects of naturally acquired immunity against subclinical and clinical hepatitis E infection using data from a placebo arm of a vaccine trial in China.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

The role of TGFβ in cancer is paradoxical and context-dependent. Here, the authors discover that a preserved, DLD-mediated metabolic suppression by TGFβ undermines anti-TGFβ therapy, promoting gastric cancer growth.

Semaglutide, a GLP-1 receptor agonist, may offer neuroprotective benefits after stroke, but its effects in large vessel occlusion (LVO) are unknown. Here the authors show, in a phase 2 randomized trial, that semaglutide is safe after endovascular therapy and may improve recovery in patients not receiving intravenous thrombolysis.

In this study, the authors develop a flavivirus vaccine strategy by introducing mutations into envelope glycoproteins resulting in structural changes that conceal the ADE-prone fusion loop epitope. They show that the Zika virus-specific construct protects mice against viral challenge and prevents ADE by Dengue virus.

This study presents a multifunctional sensor based on Te nanowires that utilizes the thermo-piezoelectric effect to achieve simultaneous sensing of strain, strain rate, and temperature.

Glioblastoma (GBM) is characterized by a high degree of heterogeneity and plasticity due to interplay with neural developmental programs. Here, the authors develop a model of GBM by introducing sequential oncogenic mutations in human neural stem cells and using this, identify INSM1 as a driver of a neural progenitor gene network promoting tumorigenesis.

Twisted two-dimensional materials are materials with fascinating properties. Here, the authors report on the incorporation of a crystallographically incompatible rotation element into two dimensional polymers to construct twist-stacked covalent organic framework nanofibers with interesting chiroptical properties.

Sun et al. reveal that root-knot nematode attack activates a phyB-HY5 cascade that integrates light and GLR3.5-CaM2 signals to boost JA synthesis in tomato, with HY5 moving from leaves to roots to sustain signaling and trigger JA-mediated defense.

This work establishes a unified ultra-wideband optical diffractive model that achieves full-band mode multiplexing across O to U telecommunication wavelengths, paving the way for ultra-high-capacity optical communications.

Here, Xiong et al investigate mid-gestational brain development from Down syndrome and control brain samples using single-nucleus RNA sequencing. They report cell-type- and region-specific transcriptional alterations associated with chr21 abnormalities.

Conventional doped spiro-OMeTAD hole transport layer often leads to poor device operational stability. Here, the authors employ light to generate protons from bistriflimide dopants in the precursor solution to increase conductivity, achieving efficiency of 20.95% in perovskite solar modules.

Here, the authors report an exome-wide association study for multi-organ imaging traits by leveraging recent bioinformatic tools such as AlphaMissense. The identified signals elucidate the genetic effects from rare variants on human organs and their connections to complex diseases

Integrating Nanopore sequencing with machine learning uncovers widespread, predictable lincRNA activation in DNA methylation-deficient Arabidopsis, linking epigenetics to RNA expression.

The skin regulatory T cells (Tregs) accumulate within the first two weeks after birth. Here the authors show that Tregs are essential for establishing skin pigmentation in newborns by modulating a molecular pathway in hair follicles, linking immune regulation to pigmentation development.

Birds uniquely exhibit high expression of constitutively active GCGR in white adipose tissue (WAT) enhancing lipid metabolism, WAT browning, and weight loss in mice. A naturally occurring human GCGRH339R mutation mimics this avian-like metabolism, suggesting therapeutic potential for obesity

This study shows that the 2025 Mw 7.7 Myanmar earthquake ruptured 500 km of the Sagaing Fault with nearly no shallow slip deficit, revealing that mature, linear strike-slip faults can release strain efficiently, unlike less mature faults.

Patient-derived glioma cell (PDGC) cultures have been poorly characterized on a molecular level. Here, the authors analyze 50 PDGC lines from glioblastoma patients using multi-omics and drug screening; find molecular subtypes that are associated with drug response and prognosis, as well as a MYC/MYCN-amplification associated with serum-free culture.

Elevated succinate in aging drives cardiac fibrosis by inducing PKM2 succinylation, dimerization, and nuclear translocation, activating fibroblasts. Targeting this axis may slow cardiac aging

Isotropic tissue magnification is integrated with matrix-assisted laser desorption/ionization mass spectrometry imaging to enable untargeted spatial proteomics at micrometre resolution and with high protein identification rates in multiple tissue types.

K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin chain is recognized by the human 26S proteasome, revealing a multivalent binding mode that underlies selective recognition.

Selective lithium extraction from low-grade brines remains a substantial challenge due to intense competition from coexisting ions such as magnesium and sodium. In pilot-scale electrochemical systems, [100]-oriented LiFePO₄ nanosheets have shown enhanced lithium selectivity, effectively isolating lithium even from brines with extremely high Na/Li and Mg/Li ratios.

Two papers report molybdenum disulfide transistors with highly scaled channel and contact lengths, which is achieved through multilayer channel optimization in one case and molecular beam epitaxy deposition of single-crystal antimony contacts in the other.

C–C bond cleavage and recombination provide an efficient strategy for the modification and reconstruction of molecular structures. Herein, the authors report a method to achieve amidation of aryl C(sp2)–H bonds by cleavage and recombination of C–C triple bonds with the participation of nitrous acid esters.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Wang, Wang, Pan and colleagues uncover a C864–C869 disulfide linkage stimulated by viral RNA that drives RIG-I activation, phase separation and stimulates downstream innate immune signalling.

T follicular helper (Tfh) cells contribute to systemic autoimmunity. However, their involvement in the pathology of lupus nephritis (LN) remains unexplored. Here, by combining single-cell analysis of LN patient tissues and humanized mouse models, the authors show that mesangial cell-derived lactate regulates Tfh cell differentiation in LN by promoting Bcl6 lactylation and subsequent stabilization via K6 and k-29-linked polyubiquitination.

This work describes FX-Cell and its derivatives to achieve single-cell RNA sequencing from challenging and cryopreserved plant tissues, expanding the scope of single-cell genomics across field-grown samples.

Reproductive success is tightly linked to nutrient availability, though how metabolism is linked to oogenesis is unclear. Here they use Drosophila for a targeted RNAi screen and identify fatty acid synthesis as a critical brake point for oocyte development.

Understanding drug targets and their effects in living cells is challenging. Here, the authors develop SICFA, a label-free proteomics method that sensitively detects drug-induced protein stability changes, thereby identifying targets and downstream pathways directly in living cells.

Droplet motion on solid surfaces has traditionally depended on static surface gradients constrained by fixed directions and coupled transport parameters. Here, shape-evolving microfiber rails (SEMRs) dynamically create cascading gradients via shape deformation, enabling steerable, adaptive droplet transport with independent control over distance and speed.

Radiosensitising agents can enhance radiotherapy and improve outcomes. Here, the authors report on the design of bioinspired Radiosensitising and biocatalytic nanoparticles to increase radiation tiggered cell death and immunogenic response to combat both primary and metastatic tumours.

Concurrent chemoradiotherapy (CCRT) has remained the standard treatment for unresectable locally advanced esophageal squamous cell carcinoma. This study presents findings from a single-arm, phase 2 clinical trial assessing the efficacy and safety of immune checkpoint blockade before CCRT.

Maintaining proper reactive oxygen species (ROS) balance is critical for cellular and individual health, yet its dynamic nature encumbers monitoring and assessment. Here the authors propose a platform using mass cytometry-based detection, termed SN-ROP, to identify distinct ROS profiles associated with specific immune cell functions and disease states.

The bacterial genotoxin colibactin induces DNA interstrand cross-links which pose a barrier to DNA replication. Here, the authors use Xenopus egg extracts to show that the Fanconi anemia pathway is responsible for repairing these cross-links.

In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and deletion of the PD-1 (PDCD1) gene were safe and associated with reduced disease activity.