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This study shows that excessive atmospheric nitrogen deposition can enhance methane production and emissions by impacting microbial phosphorus acquisition due to the change of N/P ratios in oxygenated surface oceans.

The presence of EGFR mutations and de novo MET aberrations limited response to EGFR inhibitors in patients with advance non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 randomised clinical trial investigating first-line osimertinib (EGFR inhibitor) plus savolitinib (c-MET inhibitor) in patients with MET-aberrant, EGFR-mutant advanced NSCLC.

Topological defects can be used to encode functionalities in soft matter systems. Here, authors dynamically reconfigure an acoustic lattice to create programmable topological defect arrays. The resulting velocity fields and steady acoustic streaming realign the director, enabling reversible control of defect properties and their translation.

While neoadjuvant immunotherapy and chemoradiotherapy can improve rectal cancer patient outcomes, there is a need to better identify those who will respond well. Here, the authors present a single-arm phase II trial reporting the efficacy and safety of neoadjuvant chemoradiotherapy and sintilimab (anti-PD-1) in patients with locally advanced rectal cancer with proficient mismatch repair and intermediate/high Immunoscores.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

Cryo-electron microscopy structures of the bile acid transporter OSTα–OSTβ, which has a key role in bile acid homeostasis, provide insight into its distinct architecture and mechanism of substrate translocation.

Psychedelics and their non-hallucinogenic analogues were compared, revealing that serotonin 2A receptor (5-HT_2AR)-mediated G_i signalling is essential for hallucinogenic effect, with the functional mechanisms underlying this providing insights for designing therapeutic drugs without hallucinogenic effects.

Quantum low-density parity-check error correction codes are anticipated to deliver high performance, but require long-range qubit–qubit interactions. Two of these error correction codes have now been successfully implemented on a superconducting device.

Zhang et al. found that histone deacetylase 1 (HDAC1) condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner. Disrupting the HDAC1 condensates with resminostat restores the sensitivity to temozolomide.

Powering single organic electrochemical transistor (OECT) device is challenging as power reductions can cause unstable device outputs. Wu et al. report a wearable, self-powered biosensor with a dual-OECT amplifier powered by an organic solar cell for monitoring physiological signals under varying light conditions.

Wu and colleagues present the efficacy and safety results from the phase 3 SCORES trial evaluating suvemcitug plus chemotherapy in persons with platinum-refractory or resistant recurrent ovarian cancer.

There is an unmet medical need for endometrial cancer patients with mismatch-repair proficient disease. Here, the authors report the primary analysis of the FRUSICA-1 phase Ib/II trial evaluating fruquintinib plus sintilimab in this population, showing an ORR of 32.7%, a median PFS of 8.6 months, and manageable toxicity.

Paraoxonase-1 (PON1) is a liver-specific glycoprotein that has been shown to be a tumor suppressor in hepatocellular carcinoma (HCC). Here, the authors show that PON1 reduces HCC tumor growth due to regulation of lactic acid production and regulatory T cell-mediated immunosuppression.

The residual methylammonium cation from additives compromises the operational stability of formamidinium lead iodide-based solar cells under thermal/light stress. Here, authors introduce MASCN to enhance film formation in ethyl acetate antisolvent and achieve efficiency of 26.1% for stable devices.

Shape-changing substrates are pivotal for advancing minimally invasive, conformable bioelectronics, yet their implantation is hindered by inaccessible triggering mechanisms and complex geometric fabrication. Here, the authors report a digital 4D printing technique for fabricating customized shape memory hydrogel substrates enabling trigger-free shapeshifting with predefined onset periods.

A scientific paper today is inspired by more disciplines than ever before, shows a new analysis marking the journal’s 150th anniversary.

Data heterogeneity presents a challenge in distributed artificial intelligence (AI) for medical imaging across diverse clinical settings. Here, the authors develop HeteroSync Learning, a privacy-preserving distributed learning framework that mitigates data heterogeneity and outperforms classical, state-of-the-art, and foundation models.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

The authors show that NAT10 is upregulated with T cell antigen receptor signaling and that T cell-specific NAT10 deficiency results in diminished numbers of naive T cells, translating to an inability to mount a significant antiviral T cell response.

Zero-field mobility has been an unreliable indicator to predict thick-film organic solar cell performance. Here, authors reveal that critical length is a decisive factor governing thick-film device performance and achieve maximum efficiency of 19.0% in 300-nm thick-film D18:L8-BO:BTP-eC9 devices.

Selective catalytic reduction of NOx to N₂ using methanol as the reductant (Methanol-SCR) offers a promising route for eliminating NOx emissions from methanol engines and coal-fired power plants, but its performance at low temperatures remains limited. Here, the authors identify a strategy to enhance low-temperature Methanol-SCR activity through the cooperation between zeolitic acid sites and single iron redox sites.

Single-atom catalysts (SACs) offer high atom utilization and efficiency, but their synthesis is challenging. This work realizes the mass production of sustainable SACs and demonstrates their application in vascular healing.

A matrix-confined molecular layer of compact surface coverage and good conductivity is developed as charge transport substrate to fabricate perovskite solar-cell devices with high efficiencies, which shows application potential for scalable production.

Coating additive solutions onto wet perovskite films in situ enables flexible all-perovskite tandem solar cells with a certified power conversion efficiency of 23.0% for a module with an aperture area of 20.26 cm². The modules maintain 97% of their initial efficiency after 10,000 bending cycles with a 10 mm radius.

Porous polydimethylsiloxane elastomers produced by phase separation methods often suffer from limited tribological and mechanical properties. Here, the authors describe the synthesis of porous elastomers with borate driven heterogeneous networks, improving tribological properties, with controllable pore structure and mechanical performance.

Wolbachia affects host reproduction and nutrition, but the underlying mechanisms are unclear. This study suggests Wolbachia enhances ovarian development in Laodelphax striatellus via riboflavin synthesis, driving ATP production and ovarian maturation.

Extremely high levels of dust emissions can reduce the solar photovoltaic potential by up to 70%, according to a modeling analysis for a six day extreme dust event in China in March 2021.

Soil viruses may impact soil carbon cycle. Here, the authors use metagenomic analysis of contaminated soil and 13 C labeled microcosm incubation to show that the DNA viral community enhances microbial carbon fixation capacity via auxiliary metabolic genes.

Regulating the Jahn-Teller effect in single-atom catalysts enables superior peroxymonosulfate activation. The Mn-N₄-C catalysts achieve high-efficiency water purification performance and long-term stability in simulated industrial-scale reactors.

Nonsense mutations in OTOF cause hereditary deafness. RESTART v3 achieves efficient, precise readthrough at Otof c.1315 C > T (p.R439*) sites, reinstating arginine to yield full-length, functional otoferlin, markedly restoring hearing in mice and showing strong promise for clinical translation.

Influenza B/Yamagata lineage has rarely been detected since COVID-19 non-pharmaceutical interventions were introduced, while transmission of other influenza lineages resumed. Here, the authors investigate reasons for the probable extinction of the B/Yamagata lineage by analysing viral, environmental, and host-related factors.

A dipolar-passivation strategy enables all-perovskite tandem solar cells with a power conversion efficiency of over 30%.

The diagnosis and prognosis of chronic kidney disease (CKD) relies on invasive renal biopsies, which can be clinically constrained. Here, the authors develop a non-invasive model using retinal images that can be used to screen for CKD and identify five common pathological types of CKD.

This study identifies PfAnchor as an adaptor essential for apicoplast fission and inheritance in malaria parasites, uncovering a parasite-specific mechanism that offers a new avenue for antimalarial intervention.

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Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Poly(vinylidene fluoride-co-trifluoroethylene)’s (PVDF-TrFE) piezoelectricity can be enhanced by annealing, however current annealing methods are slow. Here, the authors perform ultra-fast flash annealing of PVDF-TrFE to achieve a high piezoelectricity.

This work reveals critical role of R-Ras2 in abdominal aortic aneurysm (AAA) progression. R-Ras2 maintains VSMCs function via c-MET-TFII-I axis, with MEG3 stabilizing its mRNA stability. Findings identify R-Ras2 a potential AAA therapeutic target.

Anti-malarial immune responses involve type I IFN responses and innate immune pathways. Here the authors show the palmitoylation of TANK-binding kinase 1 (TBK1), a kinase which promotes the type I IFN pathway, is disrupted in malaria infection and that this disruption leads to less effective anti-malarial responses.

A layer-by-layer thermal evaporation strategy enables thermally evaporated inverted perovskite solar cells with a power conversion efficiency of 25.19%, maintaining about 95% of their initial efficiency after 1,000 h of operation.

Carbon materials are promising for perovskite solar cells but suffer from poor interfacial energy level alignment. Now, Zhang et al. show that Ti atomically dispersed in reduced graphene reduces energy losses improving device performance.

Self-assembled monolayers targeting wide-bandgap perovskite solar cells are essential to reduce the open-circuit voltage loss. Here, the authors report the stepwise tuning of interfacial energy level through inductive effect, achieving perovskite/TOPCon tandem solar cells with efficiency over 31%.

Polymer-coated Ag2Se for high-performance thermoelectric composite films are developed via direct-ink printing. Flexible generators demonstrate high power density and applications in heat recovery, respiratory monitoring, and energy conversion.

Researchers demonstrate mode-determined unidirectional phonon emission on a heterogeneous integrated piezoelectric substrate and showcase a minimal frequency splitter based on this phenomenon.