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Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

This study demonstrates that the reduced serum serine in patients with chemotherapy or women with poor sleep, is linked to the decline of ovarian function. Serine supplementation prevented ovarian damage in mice by inhibiting ferroptosis in ovarian granulosa cells, without affecting chemotherapy efficacy.

Heart failure affects millions worldwide with limited treatment options. Here, the authors develop a biodegradable, self-powered vagus nerve stimulator that attenuates cardiac damage at different disease stages without requiring battery replacement or surgical removal.

Reconciling broad substrate generality with high enantioselectivity remains a core limitation of enantioselective catalysis. In this study, the authors design a new-to-nature photoenzyme that unlocks enzymatic deracemization of structurally diverse allenes, an entropically disfavored process inaccessible to natural biocatalysts.

Plastic foams are widely used across industry, but petroleum-based materials are unfavorable. Here the authors report a cellulose-based molecular foam for thermal management as an environmentally friendly alternative.

Klebsiella pneumoniae clonal group 23 is a public health concern due to hypervirulence and carbapenem resistance. Here, the authors sequence 13 new isolates of the ST218-KL57 strain from China and conduct genomic analyses to investigate evolutionary divergence and resistance patterns.

The study used snMultiome-seq to map gene expression and chromatin accessibility in human central amygdala cells from people with and without AUD. Here, the authors show that inhibitory neurons are most affected, with KLF16-driven regulatory changes and AUD-risk variants disrupting gene activity.

Here the authors report that some aspects of clinical heterogeneity in type 2 diabetes vary across populations. Using a deep-learning–based tree model built from over 32,000 patients, they document disease patterns and risks specific for the Chinese population, potentially enabling more precise prediction and personalized care.

Fast reendothelialisation of vascular grafts is important for maintain patency. Here, the authors report on a vascular graft that regenerates the neo-adventitia with lymphatic endothelial cells, which increases the recruitment of circulatory progenitor cells, achieving 90% patency in small-diameter arterial grafts.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Coupling superconductors to mesoscopic systems leads to unusual effects that could be exploited in new devices including topological quantum computers. Here the authors present a double quantum dot with a Yu–Shiba–Rusinov ground state arising from the interplay of Coulomb interactions and superconductivity.

Permselective and chemically stable membrane materials for molecular separation operating under harsh conditions are currently lacking. Here, the authors report a monomer–solvent dual engineering strategy that enables the synthesis of chemically robust thiazole linked polycrystalline covalent organic framework membranes via scalable for selective molecular separation.

Neural mechanisms underlying motivation-driven behaviors are not fully understood. Here authors show that non-cholinergic neurons in rodent basal forebrain link sensory stimuli with motivational states and experience-driven plasticity.

STING–type-I interferon pathway regulates the immunogenicity of several cancer types, including head and neck squamous cell carcinoma. Here the authors describe that glutamine metabolism in the tumour microenvironment dampens the STING–type-I interferon pathway by epigenetically silencing the expression of BATF2, which functions as a tumour suppressor.

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

This work identifies the key electron-transfer limitation in electrocatalytic contaminant removal and delivers a dual-function strategy that boosts efficiency by combining molecular enrichment with precisely controlled charging-discharging.

Alzheimer’s disease is characterized by the accumulation of amyloid plaques in the brain. Here, Liu et al. develop a new method, Amyloid-ID, which uses light to label and analyze amyloid deposits in brain tissues, revealing their protein composition and associated molecules.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Dendrite growth compromises the cycling life of metal batteries. Here, authors propose a crystallographic microstructure engineering approach to the artificial solid electrolyte interphase, demonstrating a high efficacy in stabilizing the zinc metal electrode during plating/stripping.

The complex interactions between the uterus microenvironment and the embryo during development are not fully understood. Here, authors engineer a 3D hydrogel culture system to investigate how the physical and biochemical properties of the uterine microenvironment impact embryo development in vitro.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Efficient acidic CO₂ reduction to HCOOH at high current density faces challenges of high overpotential, low Faraday efficiency, and poor stability. This study optimizes these three key metrics by modulating soft acid strength through interstitial atoms.

Affinity-proteomics platforms often yield poorly correlated measurements. Here, the authors show that protein-altering variants drive a portion of inter-platform inconsistency and that accounting for genetic variants can improve concordance of protein measures and phenotypic associations across ancestries.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons.

Tuning permselectivity and chemical stability is desirable for polymer membranes, though it is challenging to balance these properties. Here the authors report a polyamide membrane using modified interfacial polymerization methods for stable and highly permeable organic solvent nanofiltration.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship between environmental antigen exposure and subsequent allergy.

A single-cell epigenomic atlas of human immune cells highlights cell-type-specific features associated with genetic or environmental exposures.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Metal nanoclusters are promising for flexible light-emitting diodes but face efficiency and stability challenges. Here, the authors employ a π-conjugated mediator to align dipole alignment, yielding devices with 26.4% external quantum efficiency and 94% efficiency retention after 2000 bending cycles.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Jahn-Teller distortions alter molecular structures, but are usually only probed on the basis of electronic signatures. Here, the authors demonstrate that tip-enhanced Raman imaging in real space can map the associated vibrational changes in a single molecule.

In an arm of an ongoing multicenter phase 2 trial testing different therapies in patients with genetically profiled grade 2 or 3 meningiomas, treatment with an oral CDK4/6 inhibitor met the primary endpoint for progression-free survival at 6 months in patients with CDK or NF2 alterations.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

A single ultrashort pulse from X-ray free-electron laser is shown to produce a submicron, with >1,000 length-to-diameter aspect ratio long channel in solid material. The results open a new avenue for development of artificial nanofluidic devices with confinement down to the molecular level.

Photocatalysis holds promise for sustainable synthesis, but AI-driven reaction prediction is hindered by limited data. Here, the authors introduce PhotoCatDB, a comprehensive database of 26.7 K reactions, and develop PhotoCat, a transformer-based tool achieving high accuracy in photocatalytic reaction prediction, retrosynthesis, and condition recommendation, as well as experimentally validate the newly discovered photocatalytic reactions.

Here, the authors present a mild nickel-catalyzed asymmetric hydroaminocarbonylation and hydrocarboxylation that use cost-effective NH₄OAc and H₂O as nucleophiles, respectively, which provides rapid access to structurally diverse cyclopropyl amides and carboxylic acids.

piR48444 targets METTL7A to inhibit BMP2 mRNA m6A methylation and METTL7A/eIF4E complex-mediated BMP2 mRNA stability and translation, ultimately inhibiting osteogenic differentiation of MSCs and bone regeneration.

Low glume coverage is the preferred for easy threshing in grain production, but the genetic basis remains unclear. Here, the authors report the gene GC1, which encodes an atypical G protein γ subunit, negatively regulates sorghum glume coverage and the naturally truncated alleles can be useful in the naked grain breeding.

An intratumoural vaccination chimera reprograms tumour cells into an antigen-presenting state with restored anti-tumour immunity.

Improved vaccines and antivirals are needed for many enveloped viruses. Here, the authors identify sulfur-based small molecules that disrupt viral membrane properties, inhibiting fusion and entry, and safely inactivate influenza virus. The resulting inactivated influenza vaccine is protective in mice.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Gut microbiota influence bone health, but the genetic and metabolic mechanisms are unclear. Here, the authors show that specific bifidobacterial taxa causally reduce bone mineral density, partly via n-3 fatty acid metabolism, highlighting host-microbe interactions with potential therapeutic implications.

Previous clinical studies suggested that Insulin-like growth factor binding-protein 7 (IGFBP7) is elevated in early stages of diabetes. Here authors showed tubule and glomerular-specific IGFBP7 promotes diabetic kidney disease.