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This study shows that micro-level uncertainty in EV charging behaviour can amplify macrolevel load variability by up to 82.7%, with marked regional differences, underscoring the need for behaviour-aware strategies to maintain power system stability.

The impact of fluorine doped tin oxide (FTO) on device longevity has been overlooked. Here, the authors employ thermal evaporated yttrium oxide to strengthen structural stability of FTO, achieving maximum efficiency of 26.48% and 28.47% in regular and all-perovskite tandem structures, respectively.

Integrated behavioural & metabolomic profiling across the mouse lifespan reveals sex-specific brain metabolic reprogramming underlying divergent trajectories of age-related cognitive decline.

Bronchiectasis and asthma can co-exist in the same patient, and the characteristics may be different from bronchiectasis alone. Here the authors characterise the function of ILC3 cells and how IL-17C potentiates IL-17A expression promoting a neutrophil dominated asthma endotype in mouse bronchiectasis-asthma models.

Monitoring charge carrier dynamics and photocatalytic reaction rates in individual photocatalyst particles is a challenging task that can help us to understand structure–reactivity relationships. Here single-molecule fluorescence imaging is coupled with femtosecond interferometric scattering microscopy to investigate these properties in 2D InSe flakes.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

He et al. report a lanthanide-doping strategy for dual-halogen-alloyed perovskite microplates, which promotes phase segregation and facilitates ion migration in the alloyed case, while suppressing it in the phase-segregated state, resulting in dual-wavelength lasing in visible spectral region.

Shape-changing substrates are pivotal for advancing minimally invasive, conformable bioelectronics, yet their implantation is hindered by inaccessible triggering mechanisms and complex geometric fabrication. Here, the authors report a digital 4D printing technique for fabricating customized shape memory hydrogel substrates enabling trigger-free shapeshifting with predefined onset periods.

An intratumoural vaccination chimera reprograms tumour cells into an antigen-presenting state with restored anti-tumour immunity.

Cascaded nonlinear optics has long enabled advances in short-wavelength generation, but equivalent approaches for long wavelengths remain underdeveloped. Here, the authors demonstrate a chip-based lithium niobate platform that delivers tunable mid-infrared light, opening new possibilities for sensing, spectroscopy, and communications.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Nitrogen-fixing bacteria offer a promising route to reduce reliance on synthetic fertilizers, but their effectiveness is hindered by environmental stresses that limit survival on leaf surfaces. This study introduces a nanocoating strategy that enables robust foliar colonization of Klebsiella variicola, enhancing nitrogen fixation and improving rice yield under low-fertilizer conditions.

Chiral α-amino acids, essential to biological systems and drug design, drive demand for precise synthetic methods to access unnatural variants (UAAs) and stereochemically defined peptides. We report an N-heterocyclic-carbene-catalyzed strategy enabling enantioselective synthesis of α-(U)AA esters and peptides.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Optical encryption provides strong data protection but has been limited by the modulating bandwidth of spatial devices. Here, the authors demonstrate a spatiotemporal noise chaffing system using conjugated orbital angular momentum modes to achieve terabit-per-second secure transmission and expand the encryption key space beyond 10¹⁰.

A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labeling and highlight the promise of DNA nanotechnology for spatially resolving enzyme reactivity with nanometer precision.

Researchers discovered five phases of brain rewiring across the lifespan. The eras of childhood, adolescence, adulthood, early aging, and late aging each have characteristic rewiring of structural connections across the whole brain.

Cutaneous tuberculosis is an infectious disease associated with extracellular matrix remodeling and granuloma-driven fibrosis. Here, the authors present an in vitro model of this disease using skin organoids infected with Mycobacterium tuberculosis, and describe infection-induced alterations in specific pathways and cell populations.

The authors find that O-GalNAc transferase 2 (GALNT2) restricts viral infection, probably through the regulation of the proteolytic processing of viral glycoproteins via its O-linked glycosylation activity, impairing virus–cell fusion.

Differentiating DCs express ALDH1A2, which produces retinoic acid and suppresses DC activity. Blocking this pathway with a new inhibitor, KyA33, enhances immune responses and boosts the effectiveness of DC cancer vaccines in mouse models.

The realization of free-electron radiation in the terahertz band with both compact device size and tunability is challenging. Here, the authors report an on-chip free-electron Cherenkov radiation source tunable from 3.2 to 14 THz at the microscale.

The synthesis of heavily substituted chiral cyclopropanes presents a significant challenge in organic chemistry due to the inherent strain and steric congestion of these three-membered rings. Here, the authors report a highly enantioselective intramolecular cyclopropanation of trisubstituted alkenes via a sulfoxonium-Rh-carbene intermediate, resulting in the formation of highly congested penta-substituted chiral cyclopropanes.

Deep crustal melt accumulation controls the shallow melt volumes and hence the eruptive capacity of polygenetic volcanoes, according to geophysical and petrological analysis.

Nuclear Factor IA is important for development and metabolism. Here, the authors present high-resolution molecular structures of Nuclear Factor IA, and detail how it recognizes the TGGCA DNA motif.

A screen for protein degraders discovers hits by imaging cell survival.

Foamy macrophages are key to atherosclerosis but poorly understood. Here, the authors show that GPNMB regulates lipoprotein processing in macrophages, exacerbating pathological lipid accumulation, and revealing it as a therapeutic target whose inhibition reduces atherosclerosis in mice.

Thermomechanical pressing and immediate quenching of electro spun nanofibers produces transparent, poling-free piezoelectric films with nearly doubled piezoelectric output and significantly improved mechanical strength.

Growth factor signalling has been shown to alleviate tissue fibrosis and promote repair. Here, the authors use fibroblast growth factor 7 (FGF7) knockout mice and an FGF7-loaded hydrogel to show that this factor can promote functional regeneration of tendon.

Moiré structures often exhibit long-range order. Here, the authors use scanning tunneling microscopy to identify an incommensurate moiré structure with a short-range-ordered charge density modulation.

This study provides prognostic models for clinical translation and reveals methylation biomarkers and mechanisms of CAD adverse outcomes.

Aberration of chromatin organisation is linked to cancer progression and cancer cell plasticity. Here, the authors investigate changes in chromatin state during the transition of cancer cells to cancer stem cells and, using a CTCF-cohesin contact reporter CRISPR screen, identify TLK2 as a driver of plasticity via regulation of chromatin loop formation.

A modular platform for engineering immunogenic lipid nanoparticle mRNA vaccines is used to display antigens from a variety of pathogens to induce antigen responses.

Triggering the natural repair processes in the body has huge potential in tissue regeneration. Here, the authors develop a bone-targeted nanoparticle that selectively eliminates osteoclasts and generates pro-regenerative apoptotic bodies, restoring bone density and treating osteoporosis.

Here, with multi-omics analyses of human cohorts and murine models, the authors identify Odoribacter splanchnicus depletion to impair intestinal P-glycoprotein function via loss of microbial, GDP-L-fucose, which in turn promotes eIF4E phosphorylation and c-Jun–driven ABCB1 expression, maintaining xenobiotic efflux.

In this study, authors evaluate mass tuberculosis (TB) screening data from 183,808 elderly individuals in China, finding that abnormal chest X-rays significantly increase TB risk.

Therapeutic gene editing in vivo is an ongoing challenge. Here, authors demonstrate Cas9 nickase guided DNA ligation as a nonviral method for installing permanent genomic corrections with favorable on target edit profiles in model animal cell types and adult mice.

This study presents the high-resolution cryo-EM structure of the ammonia monooxygenase (AMO) complex, revealing a homotrimeric assembly with five subunits, a dinuclear copper active site, a putative proton transport pathway with distinct electrostatic features for substrate handling.

This study reports graphene–amorphous carbon with interwoven networks, achieving a flexural strength of 203 MPa. Microscopy shows that crack deflection at graphene/amorphous interfaces underlies its superior performance.

Light-driven dissipative self-assembly offers precise spatiotemporal control over molecular systems, but simultaneously achieving architectural programmability and dynamic reconfigurability in such systems remains a significant challenge. Here, the authors develop a light-driven hierarchical dissipative self-assembly system using molecular-engineered coordination of dynamic macrocyclic host–guest interactions within cellulose matrices, achieving temporally programmable fluorochromism and material recyclability.

The authors demonstrate boiling suppression in a water film confined within nano/micro-structured surfaces, enabling steam generation at the boiling point without bubble formation. Leveraging this discovery, they develop a dew-point evaporative cooler capable of reducing hot air from 437 °C to 23 °C.

Achieving high output-power-density in Gallium-nitride transistors is challenging due to high thermal resistances and thick nitride layers. Here, the authors propose ion-implantation on silicon-carbide substrates, achieving high performance and reduced thermal resistance.