Search

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Host defense requires coordination between epithelial sensing and systemic responses. Here, the authors show that proton signaling links intestinal pathogen detection to motor neurons, promoting avoidance behavior and innate immunity in C. elegans.

Neutrophils are known to be important in COPD pathogenesis and calcium signaling is involved in this process. Here the authors examine the function of Na⁺Ca²⁺ exchanger 1 (NCX1) in neutrophil function in mouse models of chronic cigarette smoke exposure and show that inhibition of NCX1 reduces neutrophil accumulation in the lungs and formation of neutrophil extracellular traps (NETs).

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

Removing trace acetylene from ethylene is vital for plastic production, yet catalysts often overreact and waste the product. This work reveals that palladium dual-atom catalyst on carbon greatly speeds the reaction while keeping ethylene intact.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

This study presents a mechanistic RO model to predict ammonia transport that explicitly distinguishes NH3 and NH4 + transport and explains the pH dependence of RO performance, providing insights for the reclamation of ammonia-rich wastewater.

This study explores the role of protein hyperacetylation in heart failure with preserved ejection fraction (HFpEF). It identifies Dlat as a key regulator of mitochondrial fatty acid oxidation, offering insights for clinical HFpEF interventions.

High-nickel layered positive electrodes suffer from lattice oxygen loss and inherent lattice strain. Here, authors report a self-derived subtractive strategy to form a coherent spinel-phase shell with tunable thickness to confine active oxygen intermediates and suppresses interfacial side reactions.

The template-free synthesis of colloidal assemblies with molecule-like architectures from colloidal quantum dots holds promise for optical applications but remains challenging. Here we report a one-pot synthesis of geometries resembling sp-, sp²-, and sp³-hybridized orbitals.

The authors report acoustic microrobots with engineered cilia that could deform like bend, rotate, and change shape on demand. They use machine learning to accelerate and optimize designs for efficient actuation and future biomedical uses.

Topology is important for the properties of polymer materials, but can be difficult to control. Here, the authors report the development of conjugated oligomers with diverse topologies, each with distinct photoluminescence and photochemical properties.

Tumors remain difficult to map. Here, the authors developed a 2.5 mm magnetic-driven multifunctional optoelectronic catheter that enables minimally invasive tumor mapping, targeted drug delivery, in situ sensing, and photodynamic therapy.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

Protein detection typically requires bulky equipment and large sample volumes. Here, the authors develop a do-it-yourself plasmonic array that enables high-throughput immunoassays from minute volumes using only a pipette, showcasing their approach through longitudinal animal studies and pediatric diagnostics.

SLCO4C1 is known for regulating kidney diseases. This study showed SLCO4C1 regulates hepatic cAMP uptake to suppress lipogenesis in MASLD. Targeting this pathway by FGF21 or forskolin suppressed lipogenesis.

Metal–organic frameworks with dynamic metal–ligand bonds form reversible gates that admit enzymes larger than the pores, enabling stable encapsulation and efficient multi-enzyme cascade catalysis for glycan precursor synthesis.

African swine fever virus (ASFV) virions mainly contain capsid protein p72. Here, the authors show that host cyclophilin A binds to and stabilizes p72, promoting viral factory formation and virion assembly, thus offering a promising anti-ASFV target.

Strong optical anisotropy is commonly achieved by complex engineered materials. Here, authors synthesize elemental crystals of type-II red phosphorus made of wavy tubular structures, exhibiting strong birefringence in the visible and near-infrared spectral region. They demonstrate anisotropic photoluminescence, Raman scattering and second-harmonic generation.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Spatial principles of regulatory elements in primate cortex are poorly understood. Here, authors show a chromatin accessibility atlas identifying primate-specific cis-elements associated with psychiatric disease risks in specific cell types.

RNA-sequencing’s conversion of molecules to reads confines analysis to relative fold-changes, a metric unreliable across batches. Here, the authors introduce TranScale, a spike-in method with 100 biomimetic standards that converts reads into absolute quantities to resolve systemic biases.

A porphyrin-polydopamine photocatalyst enables efficient near-infrared light use for hydrogen peroxide production from water and oxygen, achieving high quantum efficiency and solar conversion through ultrafast electron transfer mediated by persistent radicals.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

This study from Wei-Guang Li, Tian-Le Xu and colleagues shows that neuropeptide Y released by specific hippocampal inhibitory neurons can switch fear memories into extinction memories by acting on two distinct receptor-defined neuron populations.

Solid-state lithium-sulfur batteries face practical challenges such as low utilization and cycle life. Here, authors introduce design strategies that enable practical operation, leading to the demonstration of a high loading Li₂S-anode free pouch cell that operates under “low stack pressure” of 10 MPa.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

While blue space has been linked to metabolic health, research has primarily focused on water quantity rather than quality. This study finds that lower water coverage and higher exposure to black-odorous water increase risk of metabolic syndrome.

In a prospective multi-centre cohort in China, people living in areas of high soil selenium had a 35% increased risk of incident diabetes over a 3-year study period, with a stronger effect seen for men.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Bimerons are magnetic solitons that are topologically equivalent to skyrmions in in-plane magnetized systems. This study demonstrates the room-temperature creation of bimerons in Co₈Zn₈Mn₄ via femtosecond laser pulse excitation, revealing dynamic topological control and morphological transitions of these solitons.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Using dietary data from 8,931 participants in the WELL-China cohort, this study identifies a new diet rooted in traditional Chinese food elements associated with better adherence, favourable gut microbial profiles, lower rates of central obesity and reduced incidence of major cardiovascular events, and confirms these findings in an independent Achieving Better Omics validation cohort (n = 1,851).

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Here, the authors show that residues N490 and M492 of Hepatitis E Virus capsid protein are pivotal, albeit not exclusive, host tropism determinants of hepatitis E virus (HEV) for swine infection, which enhance the understanding of HEV’s zoonotic transmission and host specificity.