Search

High yield and wide adaptation rice are crucial for grain supply and food security. Here the authors report OsPI4Kγ7 which contributes to different “adaptability-yield” trade-offs in japonica and indica, and provides an alternative breeding strategy for raising grain yield in different latitudes.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Relaxor ferroelectricity is achieved in two-dimensional CuInP₂(S_1−xSe_x)₆ crystal via controlling the monoclinic and trigonal coexist phase, enabling memristors with more analog states and lower operating voltages.

Integrating volatile optical sensing with non-volatile memory is crucial for neuromorphic vision applications. Wang et al. propose a homogeneous integration scheme that combines optoelectronic neurons and ferroelectric synapses on a single substrate for color recognition and object detection tasks.

Accurate single nucleotide variations (SNVs) detection is clinically vital, yet existing techniques can only detect SNVs at specific loci. Here, Mao et al present a new generalized CRISPR/Cas-based strategy, termed PRICE, to identify SNVs in miRNA sequences without sacrificing the sensitivity.

The study identified macrophage-derived lactate as a driver of hypertrophic scar. Lactate influx via MCT1 triggers histone lactylation in fibroblasts to activate profibrotic genes.

GLT25D1 galactosylates collagen hydroxylysines and is essential for collagen maturation. Here, authors trap multiple functional states of GLT25D1 to elucidate its molecular mechanism, providing mechanistic insights into GLT25D1-related diseases.

Here researchers reveal a microexon in the Ank3 gene encoding Ankyrin G allows cortical interneurons to fine-tune calcium signaling and firing, revealing the contribution of alternative splicing to the functional diversity among different types of neurons.

High-frequency exchange resonance in antiferromagnetically coupled ferrimagnets lasts longer than ferromagnetic resonance near the compensation point due to unequal damping in the two sublattices, promising sub-THz coherent spintronic applications.

The molecular heterogeneity of brain metastases (BrMs) poses challenges for their treatment. Here, the authors generate a multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer BrMs and identify four molecular subtypes with distinct biological and clinical features.

The instability and sluggish kinetics of conventional Cu single-atom catalysts inhibit their industrial deployment in CO₂-to-methane conversion. Here, the authors propose a d-orbital engineering strategy to construct localized Cu sites, achieving stable industrial-level electrocatalytic methanation.

It was previously shown that Zinc deficiently worsens alcoholic liver disease. This study identified muscle-derived MG53 is transported to liver and mitigates liver damage through alcohol dehydrogenase and aldehyde dehydrogenase

The catalyst-free production of H₂O₂ at hydrophobe-water micro-interfaces provides a sustainable synthesis route, yet scalability remains challenging. Here the authors demonstrate that hydrophobic macroporous resins can serve as robust, metal-free platform to construct scalable and robust hydrophobe-water interfaces for continuous H₂O₂ generation.

Polyesters from cyclic anhydrides and epoxides provide a recyclable alterative to polyolefins. Here, the authors report high molecular polyesters from phthalic anhydride and acid sensitive epoxies, such as styrene oxide, from which only low molecular weights were previously achieved.

Authors propose a pathway to design GeTe based thermoelectric materials with high thermoelectric performance and mechanical properties by nanotwin architecture and inducing high valley degeneracy.

Femtosecond X-ray solution scattering reveals how solvent environments direct the outcome of ultrafast roaming reactions in bromoform, determining whether transient hot isomers undergo rapid solvolysis or rearrange into long-lived isomeric products.

Increased glycolysis in pancreatic cancer promotes immune escape by altering the tumor microenvironment. Here, the authors show that lactate-driven histone lactylation via PCAF increases CXCL1 expression, recruiting neutrophils and enabling immunosuppression, and PCAF inhibition improves anti-PD-1 therapy in pancreatic cancer mouse models.

In maize, ZmDapF1 suppresses the activity of ZmMDH6 in chloroplasts, exacerbating oxidative damage under drought. Knocking out ZmDapF1 or using its favourable allele with lower gene expression enhances drought resilience without yield penalty.

The electrocatalytic reduction of CO₂ offers industrial potential, but elevated temperatures hinder efficient production of valuable multi-carbon compounds. Here, the authors report a synergistic electrode design for efficient CO₂ electrolysis to multicarbon products at 348 K.

Researchers develop an adaptive polymer that switches between insulating and conductive states, enabling ultra-efficient electrostatic protection for next-generation electronics at record-low additive content.

Deep brain stimulation is effective but invasive. Here, the authors develop an injectable conductive hydrogel that forms in situ and enables wireless neuromodulation under volume conduction via capacitive coupling, showing therapeutic potential in a Parkinson’s disease rat model

Talin has been believed to be indispensable for integrin activation. Here, the authors show that the curvature-sensing protein FCHo2, not talin, enables inside-out activation of integrin ɑvβ5 in curved adhesions formed at curved membranes.

Here, the authors report the nanofabrication and investigation of arrays of nanostructured MoOCl₂ realizing both hyperbolic localized plasmon resonances and chiral optical responses.

Here, the authors show that residues N490 and M492 of Hepatitis E Virus capsid protein are pivotal, albeit not exclusive, host tropism determinants of hepatitis E virus (HEV) for swine infection, which enhance the understanding of HEV’s zoonotic transmission and host specificity.

Authors find a twin-spin state in antiferromagnets, quantifies its magnetic octupole spin–orbit torque, and shows that it enables exceptionally long-distance spin transport beyond conventional spin currents.

Achieving multiple functions in a self-sustained human-machine interface remains challenging. Bai et al. show a hydrogel-based e-skin that integrates thermogalvanic, piezoionic, and diffusion mechanisms for self-powered simultaneous sensing of skin temperature, arterial pulsation, and sweat secretion.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

Osteoarthritis encompasses multiple pathological processes making it difficult to treat. Here, the authors develop ROS/MMP13 dual-responsive organic selenium hydrogel microspheres (HSPHR) to modulate intra-articular multi-tissue selenoprotein levels, achieving multimodal treatment.

Current anion exchange membrane water electrolysers are hindered by poor performance in pure water. Here, the authors report a strategy that creates built-in alkaline microenvironments, enabling high performance and long-term stability using only pure water.

The authors demonstrate that targeted protein degradation of the dengue virus capsid suppresses infection through capsid-dependent pathways rather than classical inhibition, revealing a new antiviral strategy effective against resistant viral variants.

Yin et al. report linear conjugated polymer donors with chlorinated backbone for modulating polymer aggregation and surface tension, and optimised compatibility with norfullerene acceptors. By using binary blends, a 20.42% efficiency is achieved for organic solar cells.

The study presents a 3D molecular foundation model trained across diverse biological domains to accurately predict properties of proteins and small molecules and aid in the discovery of potential antiviral compounds.

Here they identify a functional Thyroid Hormone protein precursor in ascidian, named ScTG-like, and detected the follicle-like structure for TH synthesis. These findings suggest TG-like proteins are conserved in bilaterians, providing insight into the evolution of TH synthesis.

Prostate cancer heterogeneity limits the efficacy of current therapeutic approaches. Here, the authors develop two methods, snFLARE-seq and mxFRIZNGRND, using formalin-fixed paraffin embedded samples for analysing the transcriptomic and metabolomic landscape of different anatomical origins.

Healing of infected tendons is hindered by mechanical dysfunction, tissue adhesion, and immune imbalance. Here, Li et al. develop a multifunctional Janus hydrogel with asymmetric adhesion, antibacterial properties, and pH-responsive release of tendon stem cell-derived exosomes for infected tendon repair.

Leveraging electron-phonon coupling allows for modulating self-trapped exciton formation for broadband white-light emission. Using transient spectroscopy and DFT calculations, Zhang et al. correlate the structural distortion with self-trapped exciton formation in 2D halide perovskites.

The integration of high-κ dielectrics with low equivalent oxide thickness (EOT) is crucial for the development of 2D transistors. Here, the authors report the low-temperature fabrication of wafer-scale HfO₂ dielectric films with sub-5-Å EOT and their application for the realization of high-performance 2D MoS₂ transistors and circuits.

Apomixis allows plants to reproduce clonally, yet it is unclear how rare sexual events shape their genomes. This study shows that residual sex in apomictic hickories causes recombination-driven loss of heterozygosity that exposes harmful mutations to selection and helps maintain clonality.

Many vascular‑disease risk loci lack defined causal genes. Here, the authors integrate functional genomics and CRISPR screens to identify genes influencing smooth muscle cell behaviour, validating roles for FES, BCAR1, CARF and SMARCA4, with Fes loss promoting atherosclerosis and hypertension.

Researchers report a solid that is amorphous in two dimensions but crystalline in the third, made of stacked disordered atomic layers. This shows that crystalline and amorphous order can coexist within a single material depending on direction.

This study reveals a mechanism where humidity-driven dynamic coordination between iodide ions and iodine molecules enables sustained oscillatory ion migration, providing a robust solution for continuous ambient energy harvesting

Combining generative AI and one round of wet lab evolution generates high-affinity RNA aptamers.

Dietary capsaicin alleviates Alzheimer’s disease-like pathologies in 5xFAD mice via reshaping gut bacteria and elevating the production of lipid metabolites 24-hydroxycholesterol.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

People living with HIV (PLWH) have an increased risk for aging-related comorbidities. Here, the authors develop a proteomics-based immune aging framework for PLWH and demonstrate that immune aging is accelerated in HIV infection, is closely linked to total viral reservoir burden, and is modulated by antiretroviral therapy.

Nanomaterials with chiral photoluminescence are promising candidates for advanced optical technologies. Here, the authors use mechsanochemical processing to tune the emission of circularly polarized light and enhance the nonlinear optical response in indium-based halides.

Developing camouflaging materials, which can regulate temperatures, is challenging due to contradicting optical properties. Here the authors design an aluminum-polymer which balancing camouflaging and radiative cooling properties across diverse environments.

Hydrocyclone flow fields enhance H₂ production via shear induced lattice restructuring. Here, the authors report a multiscale framework linking reactor hydrodynamics to nanoscale catalysis, guiding industrial photocatalytic H₂ production.