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RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

Tumor endothelial cells are essential stromal components in the tumor microenvironment. Here the authors find that endothelial-specific deletion of PDLIM5, an actin-binding protein, could inhibit tumor angiogenesis and tumor growth as well as enhance therapeutic responses in mouse tumor models.

The performance of π-conjugated polymers films is limited by the short exciton diffusion lengths due to local imperfections or variations in interchain packing. Here, the authors report on large-area submillimeter-scale spherulites achieved by treating a spin-coated polydiarylfluorene film under solvent vapor annealing.

Eukaryotic Fanzor proteins are compact and advantageous for delivery, but their activity remains limited. Here, the authors engineer an improved Fanzor2 system (evoMmeFz2) using structure-guided and AI-assisted strategies to enable efficient exon skipping in a Duchenne muscular dystrophy model.

Conventional organic polymeric resists and chemical solutions used in microlithographic techniques can damage sensitive materials. Here, the authors report the application of inorganic selenium molecules as a lithographic mediator and encapsulation layer during the processing of various sensitive materials, such as perovskites and black phosphorus.

Genome evolutionary history of wild Arachis species remains unclear. Here, the authors report the origin of small chromosome A08 and genome evolution of Arachis species via comparative oligopainting and genomic analysis of A. hoehnei.

Pan et al. report an N-Ni/NiCo@C catalyst for solar-driven photothermal methane dry reforming. Its designed structure enables a lattice oxygen-free reaction mechanism, achieving high efficiency and stability.

There is a need for shape memory alloys that exhibit both a large elastocaloric effect and fatigue resistance for practical, long-term solid-state cooling applications. Here authors fabricate a textured Ti₄₉Ni₅₁ alloy with high-density, epitaxially aligned Ti₄Ni₂O precipitates via controlled directional solidification, and characterize its microstructure and properties.

Chemotherapy-induced intestinal toxicity limits treatment efficacy. Here, the authors show that myeloid-derived L-kynurenine exacerbates this damage by depleting Lactobacillus johnsonii, which activates the TNFα/JNK pathway to drive epithelial apoptosis.

Conventional closed batteries are constrained by the electrical energy efficiency of 100%. Here, authors develop an open decoupled battery with an efficiency of 375% at 10 mA cm−2 through a three electrodynamic-potential design, realizing waste-to-energy conversion and electricity amplification.

Crinkler effectors were believed to exist only in pathogens. Here, the authors uncover a Crinkler‑derived genomic parasite that ADP‑ribosylates EZH2 and TRAF6 to evade epigenetic silencing and immune detection, revealing an evolutionary role for toxin‑derived proteins.

Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

This study shows that excessive atmospheric nitrogen deposition can enhance methane production and emissions by impacting microbial phosphorus acquisition due to the change of N/P ratios in oxygenated surface oceans.

Uncontrollable hemorrhage is a leading cause of preventable death. Here, Huang et al. develop a rapid, self-expanding, coagulation-promoting hemostatic powder for non-compressible hemorrhage management.

Coherent Ising machines suffer from stringent phase stabilization requirements. Here, authors provide a proof-of-concept demonstration of an optical coherent Ising machine, where spins are encoded in the polarization of light and can be accessed via intensity measurements, thereby lifting the limitations related to phase stabilization.

The authors introduce a non-invasive, ultrafast imaging method that combines femtosecond transient absorption microscopy with a WSe₂ exciton sensor to visualize multilevel exciton transport driven by correlated electronic states in twisted WS₂ moiré superlattices.

Magnet-free J-oscillators use internal spin-spin couplings in molecules and digital feedback to generate continuous, ultra-stable zero-field NMR signals, reaching up to 100x narrower linewidths for sharper molecular fingerprints.

Spin-crossover complexes are promising candidates for molecular bits owing to their magnetic bistability but engineering high-density bits is challenging due to cooperative switching dynamics. Here the authors modulate the cooperative dynamics of surface-confined spin-crossover complex chains.

Transition-metal-catalyzed nitrene strategies exhibit high efficacy for intermolecular N–H insertion, but nitrene-mediated N–N coupling under metal-free conditions has rarely been explored. Herein, the authors report the selective N–N coupling using sulfilimines as nitrene precursors.

Self-amplifying RNA enables durable therapeutic expression, but its high immunogenicity and low-fidelity replication limit its use. Here, authors engineer a Norovirus-derived VPg-saRNA platform that achieves cap-independent, low-immunogenic and precise therapeutic protein expression in vivo.

Chen et al. report a tailored self-assembled monolayer to create a localized 2D/3D perovskite heterojunction. This strategy reduces interfacial loss, achieving photovoltages >90% of thermodynamic limit for wide-bandgap cells, and enables perovskite-organic tandem solar cells with efficiency of 27.11%.

Tan and colleagues present “cycling molecular assemblies” that borrow cellular lipidation machinery to build nanostructures inside the Golgi apparatus. These tools enable rapid organelle imaging and selective destruction of cancer cells.

Woven lattices offer a pathway to highly compliant and tunable mechanical metamaterials. Here, authors present a geometric design framework for woven lattices that encodes topology and compliance, allowing for arbitrary complexity and enabling programmable large-deformation and failure responses.

Healing of infected tendons is hindered by mechanical dysfunction, tissue adhesion, and immune imbalance. Here, Li et al. develop a multifunctional Janus hydrogel with asymmetric adhesion, antibacterial properties, and pH-responsive release of tendon stem cell-derived exosomes for infected tendon repair.

Here the authors systematically benchmark 13 polygenic score (PGS) methods in UK Biobank European and African populations, revealing factors that affect prediction accuracy. They also introduce an automated platform for standardized and reproducible PGS computation.

Most studies assessing food self-sufficiency look at calories and neglect nutrient gaps. Comparing food demand and potential food production under land and water constraints, this study quantifies 9 key nutrient gaps for each of African’s 54 countries.

B7H3 is an immune checkpoint overexpressed in many cancers and associated with tumor immune evasion. Here, the authors discover that in colorectal cancer, particularly microsatellite-stable tumors, palmitic acid promotes ZDHHC24- mediated B7H3 palmitoylation, regulating CD8⁺ T cell antitumor activity.

Intermittent fasting (IF) has been recognized as a potential cancer therapeutic approach but its effect on tumor growth is limited. This study demonstrates that response to IF varies between glioblastoma subtypes, with IF specifically inhibiting Tp53-driven glioblastoma due to a reshaping of the gut microbiota and subsequent altered methionine metabolism suppressing TGF- β signaling.

Here they show that G9a-mediated H3K9me2 regulates intestinal homeostasis and injury repair through repression of cell cycle arrest genes in both mouse and human.

The efficient mass transport is the key factor to advancing the flow-electrocatalytic chemosynthesis. Here, the authors design a flow-through architecture in flow electrolyzer, reinforcing mass transport in the electrolyte to achieve the high efficiency of continuous oxime electrosynthesis.

The japonica allele of the amino acid transporter gene OsLHT1, differing from that in indica rice, enhances organic N use efficiency in high-organic-matter soils by recruiting a specific rhizosphere microbiota to boost amino acid production and uptake.

Lateral inhibition operational logic has not yet been realized in neuromorphic sensing systems at the device level. Here, the authors use a cross-channel synaptic transistor with perpendicularly integrated channels to replicate the lateral inhibition mechanism.

SleepGPT is a time-frequency foundation model for sleep decoding, built on a generative pretrained transformer, achieving superior performance in various downstream tasks across datasets.

Grain number per panicle (GNP) is a yield-determining trait of rice. Here, the authors identify a GSK3-like kinase-encoding gene GNP2 and a bZIP transcription factor-encoding gene GNP5, demonstrating their synergistic regulation of GNP and showing that specific allele combinations of these genes enhance rice yield in field conditions.

Xu et al. report that inhibition of the F-box protein FBXL2 enhances HER2 expression, rendering HER2-negative breast cancer sensitive to the anti-HER2–drug conjugate trastuzumab deruxtecan.

The efficacy of radiotherapy is sometimes hindered by the hypoxic and immunosuppressive tumor microenvironment. Chen et al. develop an injectable hydrogel encapsulating IL-12/aCTLA-4 co-engineered red blood cells, thereby alleviating hypoxia-induced radioresistance and sequentially releasing aCTLA-4/IL-12 to relieve tumor immunosuppression.

The presence of EGFR mutations and de novo MET aberrations limited response to EGFR inhibitors in patients with advance non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 randomised clinical trial investigating first-line osimertinib (EGFR inhibitor) plus savolitinib (c-MET inhibitor) in patients with MET-aberrant, EGFR-mutant advanced NSCLC.

The advancement of bioorthogonal bond-breaking chemistry requires precise spatiotemporal control over chemical reactions. Here, the authors introduce a stimuli-responsive click–release platform based on the reaction between mono-alkylhydroxylamine and cyclooctyne, enabling rapid and nearly complete payload release, and apply it to release of anticancer drugs and anaesthetics.

Zhang et al. report a foundry-compatible γ-ray treatment to induce chemical bond changes of organic contaminants in carbon nanotube transistors, mitigating the imperfections at the carbon nanotube/dielectric interface, reducing the off-state current density to 112.2 pA μm-1, and achieving radiation tolerance up to 100 Mrad(Si).

Irreversible electroporation (IRE) is a treatment for pancreatic cancer, but its efficacy is limited by uneven electric field distribution. Here, the authors show that combining iron-based nanoparticles and PROTAC-mediated degradation of ferritin heavy chain 1 (FTH1) enhances IRE efficacy by inducing ferroptosis.

The current unbalance between the performance of n-type and p-type 2D transistors limits their applications for next-generation electronics. Here, the authors report the realization of high-performance 2D MoTe₂ p-type transistors by depositing metallic tellurium contacts via thermal evaporation.

Ma et al. report an organic cation engineering strategy to improve the luminescent properties and charge transport in organic-inorganic antimony halide films, enabling red LEDs with efficiency up to 19.4% and half-lifetime of 10,190 min. Large-area (12.15 cm²) LEDs show efficiency of 14.2%.

The study used snMultiome-seq to map gene expression and chromatin accessibility in human central amygdala cells from people with and without AUD. Here, the authors show that inhibitory neurons are most affected, with KLF16-driven regulatory changes and AUD-risk variants disrupting gene activity.

On-chip circularly polarized light (CPL) detectors are relevant for various applications, but current approaches have shown a trade-off between wide spectral detection range, high discrimination ratio and high polarization sensitivity. Here, the authors report broadband high-performance CPL detectors based on twisted black phosphorus structures.

This study reports that de novo germline missense variants in SF3B1, distinct from the somatic variants frequently observed in cancer, cause a neurodevelopmental disorder and disrupt global RNA splicing.

This study presents a structural N-glycoproteome atlas of 24 mouse tissues, revealing distinct tissue-specific glycan patterns, subcellular-related protein function remodeling, and non-random co-occurrence among glycan structural features.

Using pear as a study system, the biosynthetic pathway of acetophenones has been elucidated: naturally impaired side-chain shortening of aromatic 3-ketoacyl-CoAs leads them to undergo hydrolysis, followed by decarboxylation, to yield acetophenones.

Grain number per panicle (GNP) is a critical yield component trait of rice. Here, the authors clone a MAPKKK encoding gene GNP3 positively regulating grain yield and show its role in rice panicle development by interacting and destabilizing ethylene biosynthesis related enzyme SADENOSYLMETHIONINE SYNTHETASE 1.

Here the authors show a general method to make alkoxide-based network-forming glasses with tunable properties by combining titanium, zirconium and boron-based nodes, multi-dentate alcohol linkers and mono-dentate alcohol modulators.

The potential of detecting acidic tumor microenvironment (TME) is explored for early cancer diagnosis and treatment. Here, this group reports a pH-responsive ratiometric photoacoustic sensor that dynamically monitors TME acidity throughout HCC initiation, progression, and metastasis.